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10.3390/ijms19061672 http://scihub22266oqcxt.onion/10.3390/ijms19061672 C6032156!6032156!29874855     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (6): ä Nephropedia Template TP {{tp|p=29874855|t=2018. Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health |pdf=|usr=}}{{29874855}} gab.com Text Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29874855 #FOAvip Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Recently, the mitochondrial effects of vitamin D have been characterized in many cell types. In this article, we investigated the importance of VDR not only in mitochondrial activity and integrity but also in cell health. The silencing of the receptor in different healthy, non-transformed, and cancer cells initially decreased cell growth and modulated the cell cycle. We demonstrated that, in silenced cells, the increased respiratory activity was associated with elevated reactive oxygen species (ROS) production. In the long run, the absence of the receptor caused impairment of mitochondrial integrity and, finally, cell death. Our data reveal that VDR plays a central role in protecting cells from excessive respiration and production of ROS that leads to cell damage. Because we confirmed our observations in different models of both normal and cancer cells, we conclude that VDR is essential for the health of human tissues. Twit Text FOAVip Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29874855 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29874855 #FOAvip English Wikipedia <ref>{{Cite pmid|29874855}}</ref> Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health #MMPMID29874855 Ricca C; Aillon A; Bergandi L; Alotto D; Castagnoli C; Silvagno F Int J Mol Sci 2018[Jun]; 19 (6): ä PMID29874855show ga Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Recently, the mitochondrial effects of vitamin D have been characterized in many cell types. In this article, we investigated the importance of VDR not only in mitochondrial activity and integrity but also in cell health. The silencing of the receptor in different healthy, non-transformed, and cancer cells initially decreased cell growth and modulated the cell cycle. We demonstrated that, in silenced cells, the increased respiratory activity was associated with elevated reactive oxygen species (ROS) production. In the long run, the absence of the receptor caused impairment of mitochondrial integrity and, finally, cell death. Our data reveal that VDR plays a central role in protecting cells from excessive respiration and production of ROS that leads to cell damage. Because we confirmed our observations in different models of both normal and cancer cells, we conclude that VDR is essential for the health of human tissues. äVitamin D Receptor Is Necessary for Mitochondrial Function and Cell He(epmc).pdf DeepDyve Pubget Overpricing