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10.3390/ijms19061801 http://scihub22266oqcxt.onion/10.3390/ijms19061801 C6032107!6032107!29921749     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (6): ä Nephropedia Template TP {{tp|p=29921749|t=2018. Role of Human Macrophage Polarization in Inflammation during Infectious Diseases |pdf=|usr=}}{{29921749}} gab.com Text Role of Human Macrophage Polarization in Inflammation during Infectious Diseases JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29921749 #FOAvip Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1-like and M2-like macrophages is rather represented by a continuum, where boundaries are still unclear. Indeed, human infectious diseases, are characterized by either a back and forth or often a mixed profile between the pro-inflammatory microenvironment (dominated by interleukin (IL)-1?, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-? cytokines) and tissue injury driven by classically activated macrophages (M1-like) and wound healing driven by alternatively activated macrophages (M2-like) in an anti-inflammatory environment (dominated by IL-10, Transforming growth factor (TGF)-?, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22). This review brews the complexity of the situation during infectious diseases by stressing on this continuum between M1-like and M2-like extremes. We first discuss the basic biology of macrophage polarization, function, and role in the inflammatory process and its resolution. Secondly, we discuss the relevance of the macrophage polarization continuum during infectious and neglected diseases, and the possibility to interfere with such activation states as a promising therapeutic strategy in the treatment of such diseases. Twit Text FOAVip Role of Human Macrophage Polarization in Inflammation during Infectious Diseases ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29921749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29921749 #FOAvip English Wikipedia <ref>{{Cite pmid|29921749}}</ref> Role of Human Macrophage Polarization in Inflammation during Infectious Diseases #MMPMID29921749 Atri C; Guerfali FZ; Laouini D Int J Mol Sci 2018[Jun]; 19 (6): ä PMID29921749show ga Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1-like and M2-like macrophages is rather represented by a continuum, where boundaries are still unclear. Indeed, human infectious diseases, are characterized by either a back and forth or often a mixed profile between the pro-inflammatory microenvironment (dominated by interleukin (IL)-1?, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-? cytokines) and tissue injury driven by classically activated macrophages (M1-like) and wound healing driven by alternatively activated macrophages (M2-like) in an anti-inflammatory environment (dominated by IL-10, Transforming growth factor (TGF)-?, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22). This review brews the complexity of the situation during infectious diseases by stressing on this continuum between M1-like and M2-like extremes. We first discuss the basic biology of macrophage polarization, function, and role in the inflammatory process and its resolution. Secondly, we discuss the relevance of the macrophage polarization continuum during infectious and neglected diseases, and the possibility to interfere with such activation states as a promising therapeutic strategy in the treatment of such diseases. äRole of Human Macrophage Polarization in Inflammation during Infectiou(epmc).pdf DeepDyve Pubget Overpricing