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10.3390/ijms19061575 http://scihub22266oqcxt.onion/10.3390/ijms19061575 C6032042!6032042!29799467     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29799467.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2018 ; 19 (6): ä Nephropedia Template TP {{tp|p=29799467|t=2018. Regulation of Immune Cell Function by PPARs and the Connection with Metabolic and Neurodegenerative Diseases |pdf=|usr=}}{{29799467}} gab.com Text Regulation of Immune Cell Function by PPARs and the Connection with Metabolic and Neurodegenerative Diseases JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29799467 #FOAvip Increasing evidence points towards the existence of a bidirectional interconnection between metabolic disease and neurodegenerative disorders, in which inflammation is linking both together. Activation of members of the peroxisome proliferator-activated receptor (PPAR) family has been shown to have beneficial effects in these interlinked pathologies, and these improvements are often attributed to anti-inflammatory effects of PPAR activation. In this review, we summarize the role of PPARs in immune cell function, with a focus on macrophages and T cells, and how this was shown to contribute to obesity-associated inflammation and insulin resistance, atherosclerosis, and neurodegenerative disorders. We address gender differences as a potential explanation in observed contradictory results, and we highlight PPAR-induced metabolic changes as a potential mechanism of regulation of immune cell function through these nuclear receptors. Together, immune cell-specific activation of PPARs present a promising therapeutic approach to treat both metabolic and neurodegenerative diseases. Twit Text FOAVip Regulation of Immune Cell Function by PPARs and the Connection with Metabolic and Neurodegenerative Diseases ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29799467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29799467 #FOAvip English Wikipedia <ref>{{Cite pmid|29799467}}</ref> Regulation of Immune Cell Function by PPARs and the Connection with Metabolic and Neurodegenerative Diseases #MMPMID29799467 Le Menn G; Neels JG Int J Mol Sci 2018[Jun]; 19 (6): ä PMID29799467show ga Increasing evidence points towards the existence of a bidirectional interconnection between metabolic disease and neurodegenerative disorders, in which inflammation is linking both together. Activation of members of the peroxisome proliferator-activated receptor (PPAR) family has been shown to have beneficial effects in these interlinked pathologies, and these improvements are often attributed to anti-inflammatory effects of PPAR activation. In this review, we summarize the role of PPARs in immune cell function, with a focus on macrophages and T cells, and how this was shown to contribute to obesity-associated inflammation and insulin resistance, atherosclerosis, and neurodegenerative disorders. We address gender differences as a potential explanation in observed contradictory results, and we highlight PPAR-induced metabolic changes as a potential mechanism of regulation of immune cell function through these nuclear receptors. Together, immune cell-specific activation of PPARs present a promising therapeutic approach to treat both metabolic and neurodegenerative diseases. äRegulation of Immune Cell Function by PPARs and the Connection with Me(epmc).pdf DeepDyve Pubget Overpricing