Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29802690
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Asian+Pac+J+Cancer+Prev
2018 ; 19
(5
): 1295-1302
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Therapeutic Use of Metformin in Diabetes and Survival Outcomes in Endometrial
Cancer Patients with Diabetes
#MMPMID29802690
Insin P
; Prueksaritanond N
Asian Pac J Cancer Prev
2018[May]; 19
(5
): 1295-1302
PMID29802690
show ga
Objectives: To compare survival outcomes between endometrial cancer (EC) patients
with diabetes who used metformin to those who did not use metformin. Materials
and Methods: A retrospective cohort study was conducted of EC patients who were
diabetes at the time of their cancer diagnosis and had been scheduled for
elective surgery at Rajavithi Hospital between 1 January 2003 and 31 December
2013. The patients were excluded if they had type I diabetes mellitus and a
history of other cancers. Results: Of 1,262 EC patients in the study period,
there was 212 (16.8%) patients who met the inclusion criteria. Among them, 90
(42.5%) were non-metformin users and 122 (57.5%) were metformin users. With a
median follow-up of 47 months, the 5-year overall survivals (76.4% vs 77.9%,
p=0.959) and the 5-year progression-free survivals (92.6% vs 84.7%, p=0.091) did
not significantly differ between the both groups. On Cox proportional-hazards
regression analysis, independent prognostic factors for overall survival (OS)
were FIGO stage, depth of myometrial invasion, and cervical involvement. Patients
with non-endometrioid histology and advanced stage were found to have a
significant effect on progression-free survival (PFS). However, metformin used
did not predict either OS (HR, 0.99; 95%CI, 0.56-1.73; p=0.959) or PFS (HR, 2.19;
95%CI, 0.86-5.55; p=0.099). Conclusion: Overall, a significant effect of
metformin on survival outcomes in EC patients with diabetes was not found in the
current study. Larger studies with a prospective randomized control design are
needed to clarify the benefit of metformin as a strategy for endometrial cancer
prevention and treatment.
free
free
free
