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10.3389/fcell.2018.00066 http://scihub22266oqcxt.onion/10.3389/fcell.2018.00066 C6031748!6031748!30003082     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Dev+Biol 2018 ; 6 (ä): ä Nephropedia Template TP {{tp|p=30003082|t=2018. Roles of PLODs in Collagen Synthesis and Cancer Progression |pdf=|usr=}}{{30003082}} gab.com Text Roles of PLODs in Collagen Synthesis and Cancer Progression JO: Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=30003082 #FOAvip Collagen is the major component of extracellular matrix. Collagen cross-link and deposition depend on lysyl hydroxylation, which is catalyzed by procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD). Aberrant lysyl hydroxylation and collagen cross-link contributes to the progression of many collagen-related diseases, such as fibrosis and cancer. Three lysyl hydroxylases (LH1, LH2, and LH3) are identified, encoded by PLOD1, PLOD2, and PLOD3 genes. Expression of PLODs is regulated by multiple cytokines, transcription factors and microRNAs. Dysregulation of PLODs promotes cancer progression and metastasis, suggesting that targeting PLODs is potential strategy for cancer treatment. Here, we summarize the recent progress in the investigation of function and regulation of PLODs in normal tissue development and disease progression, especially in cancer. Twit Text FOAVip Roles of PLODs in Collagen Synthesis and Cancer Progression ????Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=30003082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30003082 #FOAvip English Wikipedia <ref>{{Cite pmid|30003082}}</ref> Roles of PLODs in Collagen Synthesis and Cancer Progression #MMPMID30003082 Qi Y; Xu R Front Cell Dev Biol 2018[]; 6 (ä): ä PMID30003082show ga Collagen is the major component of extracellular matrix. Collagen cross-link and deposition depend on lysyl hydroxylation, which is catalyzed by procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD). Aberrant lysyl hydroxylation and collagen cross-link contributes to the progression of many collagen-related diseases, such as fibrosis and cancer. Three lysyl hydroxylases (LH1, LH2, and LH3) are identified, encoded by PLOD1, PLOD2, and PLOD3 genes. Expression of PLODs is regulated by multiple cytokines, transcription factors and microRNAs. Dysregulation of PLODs promotes cancer progression and metastasis, suggesting that targeting PLODs is potential strategy for cancer treatment. Here, we summarize the recent progress in the investigation of function and regulation of PLODs in normal tissue development and disease progression, especially in cancer. äRoles of PLODs in Collagen Synthesis and Cancer Progression (epmc).pdf DeepDyve Pubget Overpricing