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10.1038/s41467-018-05023-9 http://scihub22266oqcxt.onion/10.1038/s41467-018-05023-9 C6031699!6031699 !29973593     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29973593 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29973593 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 2611 Nephropedia Template TP {{tp|p=29973593 |t=2018. miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhibit tumor metastasis through improved host immunity |pdf=|usr=}}{{29973593 }} gab.com Text miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhibit tumor metastasis through improved host immunity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29973593 #FOAvip Tumor-derived soluble factors promote the production of Gr-1(+)CD11b(+) immature myeloid cells, and TGF? signaling is critical in their immune suppressive function. Here, we report that miR-130a and miR-145 directly target TGF? receptor II (T?RII) and are down-regulated in these myeloid cells, leading to increased T?RII. Ectopic expression of miR-130a and miR-145 in the myeloid cells decreased tumor metastasis. This is mediated through a downregulation of type 2 cytokines in myeloid cells and an increase in IFN?-producing cytotoxic CD8 T lymphocytes. miR-130a- and miR-145-targeted molecular networks including TGF? and IGF1R pathways were correlated with higher tumor stages in cancer patients. Lastly, miR-130a and miR-145 mimics, as well as IGF1R inhibitor NT157 improved anti-tumor immunity and inhibited metastasis in preclinical mouse models. These results demonstrated that miR-130a and miR-145 can reprogram tumor-associated myeloid cells by altering the cytokine milieu and metastatic microenvironment, thus enhancing host antitumor immunity. Twit Text FOAVip miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhibit tumor metastasis through improved host immunity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29973593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29973593 #FOAvip English Wikipedia <ref>{{Cite pmid|29973593 }}</ref> miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhibit tumor metastasis through improved host immunity #MMPMID29973593 Ishii H ; Vodnala SK ; Achyut BR ; So JY ; Hollander MC ; Greten TF ; Lal A ; Yang L Nat Commun 2018[Jul]; 9 (1 ): 2611 PMID29973593 show ga Tumor-derived soluble factors promote the production of Gr-1(+)CD11b(+) immature myeloid cells, and TGF? signaling is critical in their immune suppressive function. Here, we report that miR-130a and miR-145 directly target TGF? receptor II (T?RII) and are down-regulated in these myeloid cells, leading to increased T?RII. Ectopic expression of miR-130a and miR-145 in the myeloid cells decreased tumor metastasis. This is mediated through a downregulation of type 2 cytokines in myeloid cells and an increase in IFN?-producing cytotoxic CD8 T lymphocytes. miR-130a- and miR-145-targeted molecular networks including TGF? and IGF1R pathways were correlated with higher tumor stages in cancer patients. Lastly, miR-130a and miR-145 mimics, as well as IGF1R inhibitor NT157 improved anti-tumor immunity and inhibited metastasis in preclinical mouse models. These results demonstrated that miR-130a and miR-145 can reprogram tumor-associated myeloid cells by altering the cytokine milieu and metastatic microenvironment, thus enhancing host antitumor immunity. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |CD11b Antigen/genetics/immunology [MESH] |CD8-Positive T-Lymphocytes/drug effects/immunology/pathology [MESH] |Cell Line, Tumor [MESH] |Drug Evaluation, Preclinical [MESH] |Female [MESH] |Humans [MESH] |Immunity, Innate/*drug effects [MESH] |Injections, Intravenous [MESH] |Interferon-gamma/genetics/immunology [MESH] |Lung Neoplasms/*genetics/immunology/secondary/therapy [MESH] |Mammary Neoplasms, Experimental/*genetics/immunology/pathology/therapy [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |MicroRNAs/*genetics/immunology [MESH] |Myeloid Cells/drug effects/immunology/pathology [MESH] |Oligoribonucleotides/administration & dosage/genetics/metabolism [MESH] |Pyrogallol/analogs & derivatives/pharmacology [MESH] |Receptor, IGF Type 1/antagonists & inhibitors/genetics/immunology [MESH] |Receptor, Transforming Growth Factor-beta Type II/*genetics/immunology [MESH] |Receptors, Chemokine/genetics/immunology [MESH] |Signal Transduction [MESH] |Sulfonamides/pharmacology [MESH]miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhib(epmc).pdf DeepDyve Pubget Overpricing