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2018 ; 9
(1
): 82-86
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Malignant psoas syndrome associated with gynecological malignancy: Three case
reports and a review of the literature
#MMPMID29977543
Takamatsu S
; Murakami K
; Takaya H
; Tobiume T
; Nakai H
; Suzuki A
; Mandai M
; Matsumura N
Mol Clin Oncol
2018[Jul]; 9
(1
): 82-86
PMID29977543
show ga
Malignant psoas syndrome (MPS) is a rare and unique cancer-associated syndrome
caused by the malignant involvement of the psoas major muscle, and is
characterized by ipsilateral lumbosacral plexopathy and painful hip flexion. The
pain in MPS is often distressing and intractable, and there is no established
effective treatment approach. Herein, the present study reports on three cases of
MPS associated with gynecological malignancies, wherein symptom improvement was
observed following chemotherapy or radiotherapy. Among 39 cases documented in the
literature, female genital tract malignancies were the most frequent causes of
MPS; however, the condition may be under-diagnosed, owing to the lack of general
recognition. Considering the development of recent high-precision radiation
therapy, palliative radiotherapy may serve an important role in the management of
MPS. For physicians treating gynecological cancers, early detection of MPS is
clinically important as this may allow patients to receive possible therapies and
improve their quality of life in end-stage cancer. Further prospective studies
should be performed to evaluate effective therapeutic approaches for MPS.