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10.3904/kjim.2016.065

http://scihub22266oqcxt.onion/10.3904/kjim.2016.065
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suck abstract from ncbi


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pmid28352058
      Korean+J+Intern+Med 2018 ; 33 (4 ): 823-828
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  • The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus #MMPMID28352058
  • Son CN ; Lee TH ; Bang JH ; Jeong HJ ; Chae JN ; Lee WM ; Kim JM ; Kim SH
  • Korean J Intern Med 2018[Jul]; 33 (4 ): 823-828 PMID28352058 show ga
  • BACKGROUND/AIMS: Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE. METHODS: This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE. RESULTS: The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls (11.3 ± 5.6 µg/mL vs. 9.1 ± 2.8 µg/mL). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers. CONCLUSIONS: These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.
  • |*Biomarkers/blood [MESH]
  • |*C-Reactive Protein/analysis [MESH]
  • |*Lupus Erythematosus, Systemic/blood [MESH]
  • |Adult [MESH]
  • |Disease Progression [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Lupus Nephritis [MESH]
  • |Male [MESH]


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