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10.3389/fphar.2018.00676 http://scihub22266oqcxt.onion/10.3389/fphar.2018.00676 C6030355!6030355 !29997507     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29997507 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Pharmacol 2018 ; 9 (ä): 676 Nephropedia Template TP {{tp|p=29997507 |t=2018. Tramadol s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats |pdf=|usr=}}{{29997507 }} gab.com Text Tramadol s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=29997507 #FOAvip Tramadol is an effective pharmacological intervention in human premature ejaculation (PE). To investigate whether the inhibitory action of tramadol is primarily caused by its selective serotonin reuptake inhibitory (SSRI) effects we tested the dose-response effects of tramadol on sexual behavior in serotonin transporter wild type (SERT(+/+)), heterozygous (SERT(+/-)), and knockout (SERT(-/-)) rats. To investigate whether other mechanisms contribute to the inhibitory effects, WAY100,635, a 5-HT(1A) receptor antagonist and naloxone, a ?-opioid receptor antagonist, were tested on sexual behavior together with tramadol. Tramadol dose-dependently decreases sexual activity in all genotypes. In all studies, SERT(+/-) rats did not respond differently from SERT(+/+) rats. WAY100,635 did not affect sexual activity in SERT(+/+), but dose-dependently reduced sexual activity in SERT(-/-) rats. WAY100,635 (0.3 mg/kg) combined with tramadol (20 mg/kg) significantly reduced sexual activity in SERT(+/+) and even stronger in SERT(-/-) rats. Naloxone did not affect sexual behavior consistently in SERT(+/+) rats, while in SERT(-/-) rats all doses reduced ejaculation frequency mildly. Combining naloxone (20 mg/kg) and tramadol (20 mg/kg) decreased ejaculation frequencies in both genotypes. Interestingly, combining tramadol (20 mg/kg), WAY100,635 (0.3 mg/kg) and naloxone (20 mg/kg) led to complete elimination of all sexual activity in both SERT(+/+) and SERT(-/-) rats. These findings suggest that the inhibitory effects of tramadol on male sexual behavior in SERT(+/+) rats is mainly, if not exclusively, due to SERT inhibition, with an important role for 5-HT(1A) receptors, although influence of other systems (e.g., noradrenergic) cannot be excluded. As SSRIs exert their sexual inhibition after chronic administration, tramadol may be therapeutically attractive as "on demand" therapy for PE. Twit Text FOAVip Tramadol s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=29997507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29997507 #FOAvip English Wikipedia <ref>{{Cite pmid|29997507 }}</ref> Tramadol s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats #MMPMID29997507 Esquivel-Franco DC ; Olivier B ; Waldinger MD ; Gutiérrez-Ospina G ; Olivier JDA Front Pharmacol 2018[]; 9 (ä): 676 PMID29997507 show ga Tramadol is an effective pharmacological intervention in human premature ejaculation (PE). To investigate whether the inhibitory action of tramadol is primarily caused by its selective serotonin reuptake inhibitory (SSRI) effects we tested the dose-response effects of tramadol on sexual behavior in serotonin transporter wild type (SERT(+/+)), heterozygous (SERT(+/-)), and knockout (SERT(-/-)) rats. To investigate whether other mechanisms contribute to the inhibitory effects, WAY100,635, a 5-HT(1A) receptor antagonist and naloxone, a ?-opioid receptor antagonist, were tested on sexual behavior together with tramadol. Tramadol dose-dependently decreases sexual activity in all genotypes. In all studies, SERT(+/-) rats did not respond differently from SERT(+/+) rats. WAY100,635 did not affect sexual activity in SERT(+/+), but dose-dependently reduced sexual activity in SERT(-/-) rats. WAY100,635 (0.3 mg/kg) combined with tramadol (20 mg/kg) significantly reduced sexual activity in SERT(+/+) and even stronger in SERT(-/-) rats. Naloxone did not affect sexual behavior consistently in SERT(+/+) rats, while in SERT(-/-) rats all doses reduced ejaculation frequency mildly. Combining naloxone (20 mg/kg) and tramadol (20 mg/kg) decreased ejaculation frequencies in both genotypes. Interestingly, combining tramadol (20 mg/kg), WAY100,635 (0.3 mg/kg) and naloxone (20 mg/kg) led to complete elimination of all sexual activity in both SERT(+/+) and SERT(-/-) rats. These findings suggest that the inhibitory effects of tramadol on male sexual behavior in SERT(+/+) rats is mainly, if not exclusively, due to SERT inhibition, with an important role for 5-HT(1A) receptors, although influence of other systems (e.g., noradrenergic) cannot be excluded. As SSRIs exert their sexual inhibition after chronic administration, tramadol may be therapeutically attractive as "on demand" therapy for PE. äTramadol s Inhibitory Effects on Sexual Behavior: Pharmacological Stud(epmc).pdf DeepDyve Pubget Overpricing