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10.3389/fimmu.2018.01463 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.01463 C6030250!6030250!29997623     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29997623|t=2018. LPS-Challenged Macrophages Release Microvesicles Coated With Histones |pdf=|usr=}}{{29997623}} gab.com Text LPS-Challenged Macrophages Release Microvesicles Coated With Histones JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29997623 #FOAvip Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active process of NET formation. Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4). Here, we show that histones are also actively released by LPS-activated macrophages in association with extracellular vesicles. Vesicle-associated histones can be recovered from the plasma of mice with sepsis. Actively released histones are on the outer surface of vesicles and can interact with TLR4. Thus, activated macrophages release histones without dying, at the same time, making their DNA more accessible and communicating to other cells that infection is present. Twit Text FOAVip LPS-Challenged Macrophages Release Microvesicles Coated With Histones ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29997623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29997623 #FOAvip English Wikipedia <ref>{{Cite pmid|29997623}}</ref> LPS-Challenged Macrophages Release Microvesicles Coated With Histones #MMPMID29997623 Nair RR; Mazza D; Brambilla F; Gorzanelli A; Agresti A; Bianchi ME Front Immunol 2018[]; 9 (ä): ä PMID29997623show ga Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active process of NET formation. Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4). Here, we show that histones are also actively released by LPS-activated macrophages in association with extracellular vesicles. Vesicle-associated histones can be recovered from the plasma of mice with sepsis. Actively released histones are on the outer surface of vesicles and can interact with TLR4. Thus, activated macrophages release histones without dying, at the same time, making their DNA more accessible and communicating to other cells that infection is present. äLPS-Challenged Macrophages Release Microvesicles Coated With Histones (epmc).pdf DeepDyve Pubget Overpricing