Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/cas.13626 http://scihub22266oqcxt.onion/10.1111/cas.13626 C6029837!6029837 !29722104     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29722104 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29722104 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2018 ; 109 (7 ): 2211-2220 Nephropedia Template TP {{tp|p=29722104 |t=2018. Long noncoding RNA NORAD regulates transforming growth factor-? signaling and epithelial-to-mesenchymal transition-like phenotype |pdf=|usr=}}{{29722104 }} gab.com Text Long noncoding RNA NORAD regulates transforming growth factor- signaling and epithelial-to-mesenchymal transition-like phenotype JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=29722104 #FOAvip Long noncoding RNAs are involved in a variety of cellular functions. In particular, an increasing number of studies have revealed the functions of long noncoding RNA in various cancers; however, their precise roles and mechanisms of action remain to be elucidated. NORAD, a cytoplasmic long noncoding RNA, is upregulated by irradiation and functions as a potential oncogenic factor by binding and inhibiting Pumilio proteins (PUM1/PUM2). Here, we show that NORAD upregulates transforming growth factor-? (TGF-?) signaling and regulates TGF-?-induced epithelial-to-mesenchymal transition (EMT)-like phenotype, which is a critical step in the progression of lung adenocarcinoma, A549 cells. However, PUM1 does not appear to be involved in this process. We thus focused on importin ?1 as a binding partner of NORAD and found that knockdown of NORAD partially inhibits the physical interaction of importin ?1 with Smad3, inhibiting the nuclear accumulation of Smad complexes in response to TGF-?. Our findings may provide a new mechanism underlying the function of NORAD in cancer cells. Twit Text FOAVip Long noncoding RNA NORAD regulates transforming growth factor- signaling and epithelial-to-mesenchymal transition-like phenotype ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=29722104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29722104 #FOAvip English Wikipedia <ref>{{Cite pmid|29722104 }}</ref> Long noncoding RNA NORAD regulates transforming growth factor-? signaling and epithelial-to-mesenchymal transition-like phenotype #MMPMID29722104 Kawasaki N ; Miwa T ; Hokari S ; Sakurai T ; Ohmori K ; Miyauchi K ; Miyazono K ; Koinuma D Cancer Sci 2018[Jul]; 109 (7 ): 2211-2220 PMID29722104 show ga Long noncoding RNAs are involved in a variety of cellular functions. In particular, an increasing number of studies have revealed the functions of long noncoding RNA in various cancers; however, their precise roles and mechanisms of action remain to be elucidated. NORAD, a cytoplasmic long noncoding RNA, is upregulated by irradiation and functions as a potential oncogenic factor by binding and inhibiting Pumilio proteins (PUM1/PUM2). Here, we show that NORAD upregulates transforming growth factor-? (TGF-?) signaling and regulates TGF-?-induced epithelial-to-mesenchymal transition (EMT)-like phenotype, which is a critical step in the progression of lung adenocarcinoma, A549 cells. However, PUM1 does not appear to be involved in this process. We thus focused on importin ?1 as a binding partner of NORAD and found that knockdown of NORAD partially inhibits the physical interaction of importin ?1 with Smad3, inhibiting the nuclear accumulation of Smad complexes in response to TGF-?. Our findings may provide a new mechanism underlying the function of NORAD in cancer cells. |A549 Cells [MESH] |Carcinoma, Non-Small-Cell Lung/*pathology [MESH] |Epithelial-Mesenchymal Transition/*physiology [MESH] |Gene Expression Regulation, Neoplastic/physiology [MESH] |Humans [MESH] |Lung Neoplasms/*pathology [MESH] |Phenotype [MESH] |RNA, Long Noncoding/*metabolism [MESH] |Signal Transduction [MESH]Long noncoding RNA NORAD regulates transforming growth factor-? signal(epmc).pdf DeepDyve Pubget Overpricing