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2018 ; 13
(7
): e0198757
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Dysbiosis of oral microbiota and its association with salivary immunological
biomarkers in autoimmune liver disease
#MMPMID29969462
Abe K
; Takahashi A
; Fujita M
; Imaizumi H
; Hayashi M
; Okai K
; Ohira H
PLoS One
2018[]; 13
(7
): e0198757
PMID29969462
show ga
The gut microbiota has recently been recognized to play a role in the
pathogenesis of autoimmune liver disease (AILD), mainly primary biliary
cholangitis (PBC) and autoimmune hepatitis (AIH). This study aimed to analyze and
compare the composition of the oral microbiota of 56 patients with AILD and 15
healthy controls (HCs) and to evaluate its association with salivary
immunological biomarkers and gut microbiota. The subjects included 39 patients
with PBC and 17 patients with AIH diagnosed at our hospital. The control
population comprised 15 matched HCs. Salivary and fecal samples were collected
for analysis of the microbiome by terminal restriction fragment length
polymorphism of 16S rDNA. Correlations between immunological biomarkers measured
by Bio-Plex assay (Bio-Rad) and the oral microbiomes of patients with PBC and AIH
were assessed. Patients with AIH showed a significant increase in Veillonella
with a concurrent decrease in Streptococcus in the oral microbiota compared with
the HCs. Patients with PBC showed significant increases in Eubacterium and
Veillonella and a significant decrease in Fusobacterium in the oral microbiota
compared with the HCs. Immunological biomarker analysis showed elevated levels of
inflammatory cytokines (IL-1?, IFN-?, TNF-?, IL-8) and immunoglobulin A in the
saliva of patients with AILD. The relative abundance of Veillonella was
positively correlated with the levels of IL-1?, IL-8 and immunoglobulin A in
saliva and the relative abundance of Lactobacillales in feces. Dysbiosis of the
oral microbiota is associated with inflammatory responses and reflects changes in
the gut microbiota of patients with AILD. Dysbiosis may play an important role in
the pathogenesis of AILD.
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