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10.3324/haematol.2017.187013 http://scihub22266oqcxt.onion/10.3324/haematol.2017.187013 C6029538!6029538!29545351     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Haematologica 2018 ; 103 (7): 1124-35 Nephropedia Template TP {{tp|p=29545351|t=2018. Endothelin type A receptors mediate pain in a mouse model of sickle cell disease |pdf=|usr=}}{{29545351}} gab.com Text Endothelin type A receptors mediate pain in a mouse model of sickle cell disease JO: Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=29545351 #FOAvip Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease. We show here that the levels of endothelin-1 and its endothelin type A receptor are increased in the dorsal root ganglia of a mouse model of sickle cell disease. Pharmacologic inhibition or neuron-specific knockdown of endothelin type A receptors in primary sensory neurons of dorsal root ganglia alleviated basal and post-hypoxia evoked pain hypersensitivities in sickle cell mice. Mechanistically, endothelin type A receptors contribute to sickle cell disease-associated pain likely through the activation of NF-?B-induced Nav1.8 channel upregulation in primary sensory neurons of sickle cell mice. Our findings suggest that endothelin type A receptor is a potential target for the management of sickle cell disease-associated pain, although this expectation needs to be further verified in clinical settings. Twit Text FOAVip Endothelin type A receptors mediate pain in a mouse model of sickle cell disease ????Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=29545351 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29545351 #FOAvip English Wikipedia <ref>{{Cite pmid|29545351}}</ref> Endothelin type A receptors mediate pain in a mouse model of sickle cell disease #MMPMID29545351 Lutz BM; Wu S; Gu X; Atianjoh FE; Li Z; Fox BM; Pollock DM; Tao YX Haematologica 2018[Jul]; 103 (7): 1124-35 PMID29545351show ga Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease. We show here that the levels of endothelin-1 and its endothelin type A receptor are increased in the dorsal root ganglia of a mouse model of sickle cell disease. Pharmacologic inhibition or neuron-specific knockdown of endothelin type A receptors in primary sensory neurons of dorsal root ganglia alleviated basal and post-hypoxia evoked pain hypersensitivities in sickle cell mice. Mechanistically, endothelin type A receptors contribute to sickle cell disease-associated pain likely through the activation of NF-?B-induced Nav1.8 channel upregulation in primary sensory neurons of sickle cell mice. Our findings suggest that endothelin type A receptor is a potential target for the management of sickle cell disease-associated pain, although this expectation needs to be further verified in clinical settings. äEndothelin type A receptors mediate pain in a mouse model of sickle ce(epmc).pdf DeepDyve Pubget Overpricing