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10.1186/s12882-018-0957-7 http://scihub22266oqcxt.onion/10.1186/s12882-018-0957-7 C6029076!6029076!29970015     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Nephrol 2018 ; 19 (ä): ä Nephropedia Template TP {{tp|p=29970015|t=2018. Case report: a thiazide diuretic to treat polyuria induced by tolvaptan |pdf=|usr=}}{{29970015}} gab.com Text Case report: a thiazide diuretic to treat polyuria induced by tolvaptan JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29970015 #FOAvip Background: Currently, the vasopressin V2 receptor antagonist tolvaptan is the only available treatment for autosomal dominant polycystic kidney disease (ADPKD), but there are tolerability issues due to aquaretic side-effects such as polyuria. A possible strategy to ameliorate these side-effects may be addition of a thiazide diuretic, this is an established treatment in nephrogenic diabetes insipidus, a condition where vasopressin V2 receptor function is absent. Case presentation: We describe a 46-year-old male ADPKD-patient, who was prescribed tolvaptan, which caused polyuria of around 5 l per day. Hydrochlorothiazide was added to treat hypertension, which resulted in a marked decrease in urine production. While using tolvaptan, rate of eGFR decline was ??1.35 mL/min/1.73m2 per year, whereas after hydrochlorothiazide was initiated this was ??3.97 mL/minute/1.73m2 per year. Conclusions: This case report indicates that while addition of hydrochlorothiazide may improve tolerability of vasopressin V2 receptor antagonists, co-prescription should only be used with great scrutiny as it may decrease tolvaptan effect on rate of ADPKD disease progression. Twit Text FOAVip Case report: a thiazide diuretic to treat polyuria induced by tolvaptan ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29970015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29970015 #FOAvip English Wikipedia <ref>{{Cite pmid|29970015}}</ref> Case report: a thiazide diuretic to treat polyuria induced by tolvaptan #MMPMID29970015 Kramers BJ; van Gastel MDA; Meijer E; Gansevoort RT BMC Nephrol 2018[]; 19 (ä): ä PMID29970015show ga Background: Currently, the vasopressin V2 receptor antagonist tolvaptan is the only available treatment for autosomal dominant polycystic kidney disease (ADPKD), but there are tolerability issues due to aquaretic side-effects such as polyuria. A possible strategy to ameliorate these side-effects may be addition of a thiazide diuretic, this is an established treatment in nephrogenic diabetes insipidus, a condition where vasopressin V2 receptor function is absent. Case presentation: We describe a 46-year-old male ADPKD-patient, who was prescribed tolvaptan, which caused polyuria of around 5 l per day. Hydrochlorothiazide was added to treat hypertension, which resulted in a marked decrease in urine production. While using tolvaptan, rate of eGFR decline was ??1.35 mL/min/1.73m2 per year, whereas after hydrochlorothiazide was initiated this was ??3.97 mL/minute/1.73m2 per year. Conclusions: This case report indicates that while addition of hydrochlorothiazide may improve tolerability of vasopressin V2 receptor antagonists, co-prescription should only be used with great scrutiny as it may decrease tolvaptan effect on rate of ADPKD disease progression. äCase report: a thiazide diuretic to treat polyuria induced by tolvapta(epmc).pdf DeepDyve Pubget Overpricing