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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Allergy+Asthma+Rep
2017 ; 17
(1
): 7
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English Wikipedia
The Skin as a Route of Allergen Exposure: Part II Allergens and Role of the
Microbiome and Environmental Exposures
#MMPMID28210979
Knaysi G
; Smith AR
; Wilson JM
; Wisniewski JA
Curr Allergy Asthma Rep
2017[Jan]; 17
(1
): 7
PMID28210979
show ga
PURPOSE OF REVIEW: This second part of the article aims to highlight recent
contributions in the literature that enhance our understanding of the cutaneous
immune response to allergen. RECENT FINDINGS: Several properties of allergens
facilitate barrier disruption and cutaneous sensitization. There is a strong
epidemiologic relationship between the microbiome, both the gut and skin, and
atopic dermatitis (AD). The mechanisms connecting these two entities remain
enigmatic; however, recent murine models show that commensal skin bacteria play
an active role in supporting skin barrier homeostasis and defense against
microbial penetration. Likewise, the association between the lack of colonization
with Staph species and AD development suggests a potentially functional role for
these organisms in regulating the skin barrier and response to environmental
allergens. In undisrupted skin, evidence suggests that the cutaneous route may
promote allergen tolerance. Properties of environmental allergens and commensal
bacteria add to the complex landscape of skin immunity. Further investigation is
needed to elucidate how these properties regulate the cutaneous immune response
to allergen.