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10.1007/s00011-018-1154-7

http://scihub22266oqcxt.onion/10.1007/s00011-018-1154-7
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C6028831!6028831!29725698
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suck abstract from ncbi


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pmid29725698      Inflamm+Res 2018 ; 67 (8): 627-32
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  • SCARF1: a multifaceted, yet largely understudied, scavenger receptor #MMPMID29725698
  • Patten DA
  • Inflamm Res 2018[]; 67 (8): 627-32 PMID29725698show ga
  • Background: As is a prerequisite of belonging to the scavenger receptor super family, SCARF1 (scavenger receptor class F, member 1) is known to play a key role in the binding and endocytosis of a wide range of endogenous and exogenous ligands. Findings: Unlike most scavenger receptors, SCARF1 is an essential protein, as SCARF1-deficient mice exhibit a severe resting phenotype in which they develop systemic lupus erythematosus (SLE)-like disease, thus highlighting the importance of SCARF1-mediated clearance of apoptotic host cells in homeostasis. In addition, a number of other roles in homeostasis and disease pathology have also been suggested, including roles in both innate and adaptive immunity; however, the majority of these studies have utilised transfected cell lines engineered to ectopically express SCARF1 and very few have utilised in vivo or ex vivo approaches. Conclusion: This review summarises our current knowledge on SCARF1 biology and reflects on future directions for research on this multifaceted, yet largely understudied, scavenger receptor.
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