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10.1084/jem.20171385

http://scihub22266oqcxt.onion/10.1084/jem.20171385
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C6028508!6028508!29853607
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suck abstract from ncbi


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pmid29853607      J+Exp+Med 2018 ; 215 (7): 1891-912
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  • Itraconazole targets cell cycle heterogeneity in colorectal cancer #MMPMID29853607
  • Buczacki SJ; Popova S; Biggs E; Koukorava C; Buzzelli J; Vermeulen L; Hazelwood L; Francies H; Garnett MJ; Winton DJ
  • J Exp Med 2018[Jul]; 215 (7): 1891-912 PMID29853607show ga
  • Chemotherapy-resistant dormant colorectal cancer cells are a differentiated cell that can de-differentiate and proliferate, accounting for tumor recurrence. Itraconazole induces all tumor cells, including those dormant, to proliferate then enter senescence and is effective in multiple preclinical assays.
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