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10.1038/s41598-018-28371-4 http://scihub22266oqcxt.onion/10.1038/s41598-018-28371-4 C6028436!6028436!29967467     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29967467|t=2018. Eosinophils support adipocyte maturation and promote glucose tolerance in obesity |pdf=|usr=}}{{29967467}} gab.com Text Eosinophils support adipocyte maturation and promote glucose tolerance in obesity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29967467 #FOAvip Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small intestinal tract, which suggested the presence of impaired lipid metabolism in eosinophil-deficient ?dblGATA mice. ?dblGATA mice fed a high-fat diet (HFD) showed reduced body fat mass, impaired enlargement of adipocytes, decreased expression of adipogenic genes, and developed glucose intolerance. HFD induced accumulation of eosinophils in the perigonadal white adipose tissue. Concordantly, adipocyte-differentiated 3T3-L1 cells promoted the migration of eosinophils through the expression of CCL11 (eotaxin-1) and likely promoted their survival through the expression of interleukin (IL)-3, IL-5, and granulocyte-macrophage colony-stimulating factor. HFD-fed ?dblGATA mice showed increased infiltration of macrophages, CD4+ T-cells, and B-cells, increased expression of interferon-?, and decreased expression of IL-4 and IL-13 in white adipose tissue. Interferon-? treatment significantly decreased lipid deposition in adipocyte-differentiated 3T3-L1 cells, while IL-4 treatment promoted lipid accumulation. Notably, HFD-fed ?dblGATA mice showed increased lipid storage in the liver as compared with wild-type mice. We propose that obesity promotes the infiltration of eosinophils into adipose tissue that subsequently contribute to the metabolic homeostasis by promoting adipocyte maturation. Twit Text FOAVip Eosinophils support adipocyte maturation and promote glucose tolerance in obesity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29967467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29967467 #FOAvip English Wikipedia <ref>{{Cite pmid|29967467}}</ref> Eosinophils support adipocyte maturation and promote glucose tolerance in obesity #MMPMID29967467 Lee EH; Itan M; Jang J; Gu HJ; Rozenberg P; Mingler MK; Wen T; Yoon J; Park SY; Roh JY; Choi CS; Park WJ; Munitz A; Jung Y Sci Rep 2018[]; 8 (ä): ä PMID29967467show ga Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small intestinal tract, which suggested the presence of impaired lipid metabolism in eosinophil-deficient ?dblGATA mice. ?dblGATA mice fed a high-fat diet (HFD) showed reduced body fat mass, impaired enlargement of adipocytes, decreased expression of adipogenic genes, and developed glucose intolerance. HFD induced accumulation of eosinophils in the perigonadal white adipose tissue. Concordantly, adipocyte-differentiated 3T3-L1 cells promoted the migration of eosinophils through the expression of CCL11 (eotaxin-1) and likely promoted their survival through the expression of interleukin (IL)-3, IL-5, and granulocyte-macrophage colony-stimulating factor. HFD-fed ?dblGATA mice showed increased infiltration of macrophages, CD4+ T-cells, and B-cells, increased expression of interferon-?, and decreased expression of IL-4 and IL-13 in white adipose tissue. Interferon-? treatment significantly decreased lipid deposition in adipocyte-differentiated 3T3-L1 cells, while IL-4 treatment promoted lipid accumulation. Notably, HFD-fed ?dblGATA mice showed increased lipid storage in the liver as compared with wild-type mice. We propose that obesity promotes the infiltration of eosinophils into adipose tissue that subsequently contribute to the metabolic homeostasis by promoting adipocyte maturation. äEosinophils support adipocyte maturation and promote glucose tolerance(epmc).pdf DeepDyve Pubget Overpricing