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10.1016/j.celrep.2015.12.098 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.12.098 C6028021!6028021!26804908     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 14 (5): 1025-31 Nephropedia Template TP {{tp|p=26804908|t=2016. Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability |pdf=|usr=}}{{26804908}} gab.com Text Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26804908 #FOAvip The interplay of transcription, topological tension and chromosome breakage is a subject of intense interest, but, with so many facets to the problem, difficult to test. Here, we vary the orientation of promoters relative to one another in a yeast system that permits sensitive detection of chromosome breaks. Interestingly, convergent transcription that would direct RNA polymerases into one another does not increase chromosome breakage. In contrast, divergent transcription that would create underwound (potentially single-stranded) DNA does cause a marked increase in chromosome breakage. Furthermore, we examine the role that topoisomerases are playing in preventing genome instability at these promoters and find that Top2 is required to prevent instability at converging promoters. Twit Text FOAVip Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26804908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26804908 #FOAvip English Wikipedia <ref>{{Cite pmid|26804908}}</ref> Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability #MMPMID26804908 Pannunzio NR; Lieber MR Cell Rep 2016[Feb]; 14 (5): 1025-31 PMID26804908show ga The interplay of transcription, topological tension and chromosome breakage is a subject of intense interest, but, with so many facets to the problem, difficult to test. Here, we vary the orientation of promoters relative to one another in a yeast system that permits sensitive detection of chromosome breaks. Interestingly, convergent transcription that would direct RNA polymerases into one another does not increase chromosome breakage. In contrast, divergent transcription that would create underwound (potentially single-stranded) DNA does cause a marked increase in chromosome breakage. Furthermore, we examine the role that topoisomerases are playing in preventing genome instability at these promoters and find that Top2 is required to prevent instability at converging promoters. äDissecting the Roles of Divergent and Convergent Transcription in Chro(epmc).pdf DeepDyve Pubget Overpricing