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10.5009/gnl17443 http://scihub22266oqcxt.onion/10.5009/gnl17443 C6027831!6027831 !29699061     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29699061 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Gut+Liver 2018 ; 12 (4 ): 449-456 Nephropedia Template TP {{tp|p=29699061 |t=2018. Expression of Fibroblast Growth Factor 21 and ?-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-?B and c-Jun N-Terminal Kinase Pathways |pdf=|usr=}}{{29699061 }} gab.com Text Expression of Fibroblast Growth Factor 21 and -Klotho Regulates Hepatic Fibrosis through the Nuclear Factor- B and c-Jun N-Terminal Kinase Pathways JO: Gut Liver http://www.kidney.de/pget.php?&tw=1&pmid=29699061 #FOAvip BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the ?-Klotho and FGF21 pathway in the liver. METHODS: Enrolled patients had biopsy-confirmed viral or alcoholic hepatitis. FGF19, FGF21 and ?-Klotho levels were evaluated using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blotting. Furthermore, we explored the underlying mechanisms for this process by evaluating nuclear factor-?B (NF-?B) and c-Jun N-terminal kinase (JNK) pathway involvement in Huh-7 cells. RESULTS: We observed that the FGF19 and FGF21 serum and mRNA levels in the biopsied liver tissue gradually increased and were correlated with fibrosis stage. Inflammatory markers (interleukin 1? [IL-1?], IL-6, and tumor necrosis factor-?) were positively correlated, while ?-Klotho expression was negatively correlated with the degree of fibrosis. In Huh-7 cells, IL-1? increased FGF21 levels and decreased ?-Klotho levels. NF-?B and JNK inhibitors abolished the effect of IL-1? on both FGF21 and ?-Klotho expression. FGF21 protected IL-1?-induced growth retardation in Huh-7 cells. CONCLUSIONS: These results indicate that the inflammatory response during fibrogenesis increases FGF21 levels and suppresses ?-Klotho via the NF-?B and JNK pathway. In addition, FGF21 likely protects hepatocytes from hepatic inflammation and fibrosis. Twit Text FOAVip Expression of Fibroblast Growth Factor 21 and -Klotho Regulates Hepatic Fibrosis through the Nuclear Factor- B and c-Jun N-Terminal Kinase Pathways ????Gut Liver http://www.kidney.de/pget.php?&tw=1&pmid=29699061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29699061 #FOAvip English Wikipedia <ref>{{Cite pmid|29699061 }}</ref> Expression of Fibroblast Growth Factor 21 and ?-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-?B and c-Jun N-Terminal Kinase Pathways #MMPMID29699061 Lee KJ ; Jang YO ; Cha SK ; Kim MY ; Park KS ; Eom YW ; Baik SK Gut Liver 2018[Jul]; 12 (4 ): 449-456 PMID29699061 show ga BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the ?-Klotho and FGF21 pathway in the liver. METHODS: Enrolled patients had biopsy-confirmed viral or alcoholic hepatitis. FGF19, FGF21 and ?-Klotho levels were evaluated using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blotting. Furthermore, we explored the underlying mechanisms for this process by evaluating nuclear factor-?B (NF-?B) and c-Jun N-terminal kinase (JNK) pathway involvement in Huh-7 cells. RESULTS: We observed that the FGF19 and FGF21 serum and mRNA levels in the biopsied liver tissue gradually increased and were correlated with fibrosis stage. Inflammatory markers (interleukin 1? [IL-1?], IL-6, and tumor necrosis factor-?) were positively correlated, while ?-Klotho expression was negatively correlated with the degree of fibrosis. In Huh-7 cells, IL-1? increased FGF21 levels and decreased ?-Klotho levels. NF-?B and JNK inhibitors abolished the effect of IL-1? on both FGF21 and ?-Klotho expression. FGF21 protected IL-1?-induced growth retardation in Huh-7 cells. CONCLUSIONS: These results indicate that the inflammatory response during fibrogenesis increases FGF21 levels and suppresses ?-Klotho via the NF-?B and JNK pathway. In addition, FGF21 likely protects hepatocytes from hepatic inflammation and fibrosis. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Female [MESH] |Fibroblast Growth Factors/*blood [MESH] |Hepatitis, Alcoholic/*blood/complications/pathology [MESH] |Hepatitis, Viral, Human/*blood/complications/pathology [MESH] |Hepatocytes/metabolism [MESH] |Humans [MESH] |JNK Mitogen-Activated Protein Kinases/*metabolism [MESH] |Klotho Proteins [MESH] |Liver Cirrhosis/etiology [MESH] |Liver/cytology/metabolism/pathology [MESH] |Male [MESH] |Membrane Proteins/*blood [MESH] |Middle Aged [MESH] |NF-kappa B/*metabolism [MESH] |Signal Transduction/*physiology [MESH]Expression of Fibroblast Growth Factor 21 and ?-Klotho Regulates Hepat(epmc).pdf DeepDyve Pubget Overpricing