Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29984212
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Hepatocell+Carcinoma
2018 ; 5
(ä): 61-73
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of Wnt/?-catenin signaling in hepatocellular carcinoma, pathogenesis, and
clinical significance
#MMPMID29984212
Khalaf AM
; Fuentes D
; Morshid AI
; Burke MR
; Kaseb AO
; Hassan M
; Hazle JD
; Elsayes KM
J Hepatocell Carcinoma
2018[]; 5
(ä): 61-73
PMID29984212
show ga
Hepatocellular carcinoma (HCC) is one of the most common primary hepatic
malignancies and one of the fastest-growing causes of cancer-related mortality in
the United States. The molecular basis of HCC carcinogenesis has not been clearly
identified. Among the molecular signaling pathways implicated in the pathogenesis
of HCC, the Wnt/?-catenin signaling pathway is one of the most frequently
activated. A great effort is under way to clearly understand the role of this
pathway in the pathogenesis of HCC and its role in the transition from chronic
liver diseases, including viral hepatitis, to hepatocellular adenomas (HCAs) and
HCCs and its targetability in novel therapies. In this article, we review the
role of the ?-catenin pathway in hepatocarcinogenesis and progression from
chronic inflammation to HCC, the novel potential treatments targeting the pathway
and its prognostic role in HCC patients, as well as the imaging features of HCC
and their association with aberrant activation of the pathway.