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2018 ; 7
(2
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cerebrospinal Fluid Concentrations of Biogenic Amines: Potential Biomarkers for
Diagnosis of Bacterial and Viral Meningitis
#MMPMID29652804
Taj A
; Jamil N
Pathogens
2018[Apr]; 7
(2
): ä PMID29652804
show ga
Catecholamine and serotonin are biogenic amines (BAs) that serve as
neurotransmitters and play an important role in the regulation of cardinal
functions that are mainly altered during central nervous system (CNS) infections.
A total 92 samples of cerebrospinal fluid (CSF) were classified into 4 groups
based on their etiology. In these samples, BAs/neurotransmitters i.e., dopamine
(DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and
5-hydroxyindoleacetic acid (5HIAA) were detected and quantified by high
performance liquid chromatography with electrochemical detection (HPLC-EC) to
determine the neurophysiology of the CNS infections by bacteria (Listeria
monocytogenes (Lm) and Neisseria meningitidis (Nm)) and herpes simplex virus
(HSV). CSF concentration of DA, DOPAC, HVA, and 5HIAA were found significantly
elevated in all test cohorts. Present study highlights that the analysis of BAs
is pivotal for the early diagnosis of bacterial and viral meningitis. In
addition, coinfections of varied etiology can also be diagnosed by their
quantification. Thus, BAs can serve as potential biomarkers of these CNS
infections.