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2018 ; 6
(2
): ä Nephropedia Template TP
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HIF Oxygen Sensing Pathways in Lung Biology
#MMPMID29882755
Urrutia AA
; Aragonés J
Biomedicines
2018[Jun]; 6
(2
): ä PMID29882755
show ga
Cellular responses to oxygen fluctuations are largely mediated by
hypoxia-inducible factors (HIFs). Upon inhalation, the first organ inspired
oxygen comes into contact with is the lungs, but the understanding of the
pulmonary HIF oxygen-sensing pathway is still limited. In this review we will
focus on the role of HIF1α and HIF2α isoforms in lung responses to
oxygen insufficiency. In particular, we will discuss novel findings regarding
their role in the biology of smooth muscle cells and endothelial cells in the
context of hypoxia-induced pulmonary vasoconstriction. Moreover, we will also
discuss recent studies into HIF-dependent responses in the airway epithelium,
which have been even less studied than the HIF-dependent vascular responses in
the lungs. In summary, we will review the biological functions executed by HIF1
or HIF2 in the pulmonary vessels and epithelium to control lung responses to
oxygen fluctuations as well as their pathological consequences in the hypoxic
lung.
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