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10.3390/biomedicines6020068 http://scihub22266oqcxt.onion/10.3390/biomedicines6020068 C6027477!6027477!29882755     free     free     free       Biomedicines 2018 ; 6 (2): ä Nephropedia Template TP {{tp|p=29882755|t=2018. HIF Oxygen Sensing Pathways in Lung Biology |pdf=|usr=}}{{29882755}} gab.com Text HIF Oxygen Sensing Pathways in Lung Biology JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=29882755 #FOAvip Cellular responses to oxygen fluctuations are largely mediated by hypoxia-inducible factors (HIFs). Upon inhalation, the first organ inspired oxygen comes into contact with is the lungs, but the understanding of the pulmonary HIF oxygen-sensing pathway is still limited. In this review we will focus on the role of HIF1? and HIF2? isoforms in lung responses to oxygen insufficiency. In particular, we will discuss novel findings regarding their role in the biology of smooth muscle cells and endothelial cells in the context of hypoxia-induced pulmonary vasoconstriction. Moreover, we will also discuss recent studies into HIF-dependent responses in the airway epithelium, which have been even less studied than the HIF-dependent vascular responses in the lungs. In summary, we will review the biological functions executed by HIF1 or HIF2 in the pulmonary vessels and epithelium to control lung responses to oxygen fluctuations as well as their pathological consequences in the hypoxic lung. Twit Text FOAVip HIF Oxygen Sensing Pathways in Lung Biology ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=29882755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29882755 #FOAvip English Wikipedia <ref>{{Cite pmid|29882755}}</ref> HIF Oxygen Sensing Pathways in Lung Biology #MMPMID29882755 Urrutia AA; Aragonés J Biomedicines 2018[Jun]; 6 (2): ä PMID29882755show ga Cellular responses to oxygen fluctuations are largely mediated by hypoxia-inducible factors (HIFs). Upon inhalation, the first organ inspired oxygen comes into contact with is the lungs, but the understanding of the pulmonary HIF oxygen-sensing pathway is still limited. In this review we will focus on the role of HIF1? and HIF2? isoforms in lung responses to oxygen insufficiency. In particular, we will discuss novel findings regarding their role in the biology of smooth muscle cells and endothelial cells in the context of hypoxia-induced pulmonary vasoconstriction. Moreover, we will also discuss recent studies into HIF-dependent responses in the airway epithelium, which have been even less studied than the HIF-dependent vascular responses in the lungs. In summary, we will review the biological functions executed by HIF1 or HIF2 in the pulmonary vessels and epithelium to control lung responses to oxygen fluctuations as well as their pathological consequences in the hypoxic lung. äHIF Oxygen Sensing Pathways in Lung Biology (epmc).pdf DeepDyve Pubget Overpricing