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2018 ; 10
(2
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Review of Intraocular Pharmacokinetics of Anti-Infectives Commonly Used in the
Treatment of Infectious Endophthalmitis
#MMPMID29844284
Luaces-Rodríguez A
; González-Barcia M
; Blanco-Teijeiro MJ
; Gil-Martínez M
; Gonzalez F
; Gómez-Ulla F
; Lamas MJ
; Otero-Espinar FJ
; Fernández-Ferreiro A
Pharmaceutics
2018[May]; 10
(2
): ä PMID29844284
show ga
Although intravitreal administration of anti-infectives represents the standard
treatment for infectious endophthalmitis, the knowledge about their
pharmacokinetics is still limited. In this review, we aimed to summarise the
factors influencing the pharmacokinetics of the anti-infective agents. We have
conducted a comprehensive review of the preclinical pharmacokinetic parameters
obtained in different studies of intravitreal injections of anti-infectives
performed on animals, mainly rabbits. The two aspects with the biggest influence
on pharmacokinetics are the distribution in the vitreous humour and the
elimination through the posterior segment. The distribution can be affected by
the molecular weight of the drug, the convection flow of the vitreous, the
condition of the vitreous humour depending on the age of the patient, the
possible interactions between the drug and the components of the vitreous, and
the presence of vitrectomy. Meanwhile, the elimination includes the metabolism of
the drug, the clearance via the anterior and posterior routes, and the possible
inflammation of the eye resulting from the disease. Understanding the
pharmacokinetics of the anti-infectives used in clinical practice is essential
for a correct application. The information provided in this review could offer
guidance for selecting the best therapeutic option according to the
characteristics of the drugs.
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