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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Drug+Deliv+Rev 2017 ; 114 (ä): 43-59 Nephropedia Template TP
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Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges? #MMPMID28694027
Maisel K; Sasso MS; Potin L; Swartz MA
Adv Drug Deliv Rev 2017[May]; 114 (ä): 43-59 PMID28694027show ga
Lymphatic vessels are the primary route of communication from peripheral tissues to the immune system; as such, they represent an important component of local immunity. In addition to their transport functions, new immunomodulatory roles for lymphatic vessels and lymphatic endothelial cells have come to light in recent years, demonstrating that lymphatic vessels help shape immune responses in a variety of ways: promoting tolerance to self-antigens, archiving antigen for later presentation, dampening effector immune responses, and resolving inflammation, among others. In addition to these new biological insights, the growing field of immunoengineering has begun to explore therapeutic approaches to utilize or exploit the lymphatic system for immunotherapy.