Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.molmet.2018.05.004 http://scihub22266oqcxt.onion/10.1016/j.molmet.2018.05.004 C6026319!6026319!29799418     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Metab 2018 ; 13 (ä): 30-44 Nephropedia Template TP {{tp|p=29799418|t=2018. Osteoglycin, a novel coordinator of bone and glucose homeostasis |pdf=|usr=}}{{29799418}} gab.com Text Osteoglycin, a novel coordinator of bone and glucose homeostasis JO: Mol Metab http://www.kidney.de/pget.php?&tw=1&pmid=29799418 #FOAvip Objective: The skeleton, which is strongly controlled by endocrine factors, has recently been shown to also play an active endocrine role itself, specifically influencing energy metabolism. However, much less is known about this role. Therefore, we sought to identify novel endocrine factors involved in the regulation of both bone mass and whole-body glucose homeostasis. Methods: We used transcriptomic and proteomic analysis of Y1 receptor deficient osteoblasts combined with the generation of a novel osteoglycin deficient mouse model and performed comprehensive in vivo phenotype profiling, combined with osteoglycin administration in wildtype mice and human studies. Results: Here we identify a novel role for osteoglycin, a secreted proteoglycan, in coordinating bone accretion with changes in energy balance. Using an osteoglycin knockout mouse model, we show that at a whole body level, osteoglycin acts to suppress bone formation and modulate whole body energy supplies by altering glucose uptake through changes in insulin secretion and sensitivity, as well as by altering food intake through central signaling. Examining humans following gastric surgery as a model of negative energy balance, we show that osteoglycin is associated with BMI and lean mass as well as changes in weight, BMI, and glucose levels. Conclusions: Thus, we identify osteoglycin as a novel factor involved in the regulation of energy homeostasis and identify a role for it in facilitating the matching of bone acquisition to alterations in energy status. Twit Text FOAVip Osteoglycin, a novel coordinator of bone and glucose homeostasis ????Mol Metab http://www.kidney.de/pget.php?&tw=1&pmid=29799418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29799418 #FOAvip English Wikipedia <ref>{{Cite pmid|29799418}}</ref> Osteoglycin, a novel coordinator of bone and glucose homeostasis #MMPMID29799418 Lee N; Ali N; Zhang L; Qi Y; Clarke I; Enriquez R; Brzozowska M; Lee I; Rogers M; Laybutt D; Center J; Baldock P; Herzog H Mol Metab 2018[Jul]; 13 (ä): 30-44 PMID29799418show ga Objective: The skeleton, which is strongly controlled by endocrine factors, has recently been shown to also play an active endocrine role itself, specifically influencing energy metabolism. However, much less is known about this role. Therefore, we sought to identify novel endocrine factors involved in the regulation of both bone mass and whole-body glucose homeostasis. Methods: We used transcriptomic and proteomic analysis of Y1 receptor deficient osteoblasts combined with the generation of a novel osteoglycin deficient mouse model and performed comprehensive in vivo phenotype profiling, combined with osteoglycin administration in wildtype mice and human studies. Results: Here we identify a novel role for osteoglycin, a secreted proteoglycan, in coordinating bone accretion with changes in energy balance. Using an osteoglycin knockout mouse model, we show that at a whole body level, osteoglycin acts to suppress bone formation and modulate whole body energy supplies by altering glucose uptake through changes in insulin secretion and sensitivity, as well as by altering food intake through central signaling. Examining humans following gastric surgery as a model of negative energy balance, we show that osteoglycin is associated with BMI and lean mass as well as changes in weight, BMI, and glucose levels. Conclusions: Thus, we identify osteoglycin as a novel factor involved in the regulation of energy homeostasis and identify a role for it in facilitating the matching of bone acquisition to alterations in energy status. äOsteoglycin, a novel coordinator of bone and glucose homeostasis (epmc).pdf DeepDyve Pubget Overpricing