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10.3390/cancers10060155 http://scihub22266oqcxt.onion/10.3390/cancers10060155 C6025289!6025289!29794999     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29794999&cmd=llinks): Failed to open stream: HTTP request failed! 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Targeted Tumor Therapy Remixed?An Update on the Use of Small-Molecule Drugs in Combination Therapies |pdf=|usr=}}{{29794999}} gab.com Text Targeted Tumor Therapy Remixed An Update on the Use of Small-Molecule Drugs in Combination Therapies JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29794999 #FOAvip Over the last decade, the treatment of tumor patients has been revolutionized by the highly successful introduction of novel targeted therapies, in particular small-molecule kinase inhibitors and monoclonal antibodies, as well as by immunotherapies. Depending on the mutational status, BRAF and MEK inhibitor combinations or immune checkpoint inhibitors are current first-line treatments for metastatic melanoma. However, despite great improvements of survival rates limitations due to tumor heterogeneity, primary and acquired therapy resistance, immune evasion, and economical considerations will need to be overcome. Accordingly, ongoing clinical trials explore the individualized use of small-molecule drugs in new targeted therapy combinations based on patient parameters and tumor biopsies. With focus on melanoma therapy this review aims at providing a comprehensive overview of such novel alternative and combinational therapy strategies currently emerging from basic research. The molecular principles and drug classes that may hold promise for improved tumor therapy combination regimens including kinase inhibition, induction of apoptosis, DNA-damage response inhibition, epigenetic reprogramming, telomerase inhibition, redox modulation, metabolic reprogramming, proteasome inhibition, cancer stem cell transdifferentiation, immune cell signaling modulation, and others, are explained in brief. In addition, relevant targeted therapy combinations in current clinical trials and individualized treatment strategies are highlighted. Twit Text FOAVip Targeted Tumor Therapy Remixed An Update on the Use of Small-Molecule Drugs in Combination Therapies ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29794999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29794999 #FOAvip English Wikipedia <ref>{{Cite pmid|29794999}}</ref> Targeted Tumor Therapy Remixed?An Update on the Use of Small-Molecule Drugs in Combination Therapies #MMPMID29794999 Gatzka MV Cancers (Basel) 2018[Jun]; 10 (6): ä PMID29794999show ga Over the last decade, the treatment of tumor patients has been revolutionized by the highly successful introduction of novel targeted therapies, in particular small-molecule kinase inhibitors and monoclonal antibodies, as well as by immunotherapies. Depending on the mutational status, BRAF and MEK inhibitor combinations or immune checkpoint inhibitors are current first-line treatments for metastatic melanoma. However, despite great improvements of survival rates limitations due to tumor heterogeneity, primary and acquired therapy resistance, immune evasion, and economical considerations will need to be overcome. Accordingly, ongoing clinical trials explore the individualized use of small-molecule drugs in new targeted therapy combinations based on patient parameters and tumor biopsies. With focus on melanoma therapy this review aims at providing a comprehensive overview of such novel alternative and combinational therapy strategies currently emerging from basic research. The molecular principles and drug classes that may hold promise for improved tumor therapy combination regimens including kinase inhibition, induction of apoptosis, DNA-damage response inhibition, epigenetic reprogramming, telomerase inhibition, redox modulation, metabolic reprogramming, proteasome inhibition, cancer stem cell transdifferentiation, immune cell signaling modulation, and others, are explained in brief. In addition, relevant targeted therapy combinations in current clinical trials and individualized treatment strategies are highlighted. äTargeted Tumor Therapy Remixed?An Update on the Use of Small-Molecule (epmc).pdf DeepDyve Pubget Overpricing