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10.3390/cancers10060194 http://scihub22266oqcxt.onion/10.3390/cancers10060194 C6025055!6025055!29891791     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancers+(Basel) 2018 ; 10 (6): ä Nephropedia Template TP {{tp|p=29891791|t=2018. TGF-? in T Cell Biology: Implications for Cancer Immunotherapy |pdf=|usr=}}{{29891791}} gab.com Text TGF- in T Cell Biology: Implications for Cancer Immunotherapy JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29891791 #FOAvip Transforming Growth Factor beta (TGF-?) is a pleiotropic cytokine produced in large amounts within cancer microenvironments that will ultimately promote neoplastic progression, notably by suppressing the host?s T-cell immunosurveillance. This effect is mostly due to the well-known inhibitory effect of TGF-? on T cell proliferation, activation, and effector functions. Moreover, TGF-? subverts T cell immunity by favoring regulatory T-cell differentiation, further reinforcing immunosuppression within tumor microenvironments. These findings stimulated the development of many strategies to block TGF-? or its signaling pathways, either as monotherapy or in combination with other therapies, to restore anti-cancer immunity. Paradoxically, recent studies provided evidence that TGF-? can also promote differentiation of certain inflammatory populations of T cells, such as Th17, Th9, and resident-memory T cells (Trm), which have been associated with improved tumor control in several models. Here, we review current advances in our understanding of the many roles of TGF-? in T cell biology in the context of tumor immunity and discuss the possibility to manipulate TGF-? signaling to improve cancer immunotherapy. Twit Text FOAVip TGF- in T Cell Biology: Implications for Cancer Immunotherapy ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29891791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29891791 #FOAvip English Wikipedia <ref>{{Cite pmid|29891791}}</ref> TGF-? in T Cell Biology: Implications for Cancer Immunotherapy #MMPMID29891791 Dahmani A; Delisle JS Cancers (Basel) 2018[Jun]; 10 (6): ä PMID29891791show ga Transforming Growth Factor beta (TGF-?) is a pleiotropic cytokine produced in large amounts within cancer microenvironments that will ultimately promote neoplastic progression, notably by suppressing the host?s T-cell immunosurveillance. This effect is mostly due to the well-known inhibitory effect of TGF-? on T cell proliferation, activation, and effector functions. Moreover, TGF-? subverts T cell immunity by favoring regulatory T-cell differentiation, further reinforcing immunosuppression within tumor microenvironments. These findings stimulated the development of many strategies to block TGF-? or its signaling pathways, either as monotherapy or in combination with other therapies, to restore anti-cancer immunity. Paradoxically, recent studies provided evidence that TGF-? can also promote differentiation of certain inflammatory populations of T cells, such as Th17, Th9, and resident-memory T cells (Trm), which have been associated with improved tumor control in several models. Here, we review current advances in our understanding of the many roles of TGF-? in T cell biology in the context of tumor immunity and discuss the possibility to manipulate TGF-? signaling to improve cancer immunotherapy. äTGF-? in T Cell Biology: Implications for Cancer Immunotherapy (epmc).pdf DeepDyve Pubget Overpricing