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10.3390/cancers10060176 http://scihub22266oqcxt.onion/10.3390/cancers10060176 C6024970!6024970!29865211     free     free     free       Cancers+(Basel) 2018 ; 10 (6): ä Nephropedia Template TP {{tp|p=29865211|t=2018. Emerging and Established Models of Bone Metastasis |pdf=|usr=}}{{29865211}} gab.com Text Emerging and Established Models of Bone Metastasis JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29865211 #FOAvip Metastasis is the leading cause of cancer-related death and drives patient morbidity as well as healthcare costs. Bone is the primary site of metastasis for several cancers?breast and prostate cancers in particular. Efforts to treat bone metastases have been stymied by a lack of models to study the progression, cellular players, and signaling pathways driving bone metastasis. In this review, we examine newly described and classic models of bone metastasis. Through the use of current in vivo, microfluidic, and in silico computational bone metastasis models we may eventually understand how cells escape the primary tumor and how these circulating tumor cells then home to and colonize the bone marrow. Further, future models may uncover how cells enter and then escape dormancy to develop into overt metastases. Recreating the metastatic process will lead to the discovery of therapeutic targets for disrupting and treating bone metastasis. Twit Text FOAVip Emerging and Established Models of Bone Metastasis ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29865211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29865211 #FOAvip English Wikipedia <ref>{{Cite pmid|29865211}}</ref> Emerging and Established Models of Bone Metastasis #MMPMID29865211 Jinnah AH; Zacks BC; Gwam CU; Kerr BA Cancers (Basel) 2018[Jun]; 10 (6): ä PMID29865211show ga Metastasis is the leading cause of cancer-related death and drives patient morbidity as well as healthcare costs. Bone is the primary site of metastasis for several cancers?breast and prostate cancers in particular. Efforts to treat bone metastases have been stymied by a lack of models to study the progression, cellular players, and signaling pathways driving bone metastasis. In this review, we examine newly described and classic models of bone metastasis. Through the use of current in vivo, microfluidic, and in silico computational bone metastasis models we may eventually understand how cells escape the primary tumor and how these circulating tumor cells then home to and colonize the bone marrow. Further, future models may uncover how cells enter and then escape dormancy to develop into overt metastases. Recreating the metastatic process will lead to the discovery of therapeutic targets for disrupting and treating bone metastasis. äEmerging and Established Models of Bone Metastasis (epmc).pdf DeepDyve Pubget Overpricing