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2018 ; 6
(2
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Role of Systems Biologic Approach in Cell Signaling and Drug Development
Responses-A Mini Review
#MMPMID29848999
Abhyankar V
; Bland P
; Fernandes G
Med Sci (Basel)
2018[May]; 6
(2
): ä PMID29848999
show ga
The immune system is an integral aspect of the human defense system and is
primarily responsible for and involved in the communication between the immune
cells. It also plays an important role in the protection of the organism from
foreign invaders. Recent studies in the literature have described its role in the
process of hematopoiesis, lymphocyte recruitment, T cell subset differentiation
and inflammation. However, the specific molecular mechanisms underlying these
observations remain elusive, impeding the elaborate manipulation of cytokine
sequential delivery in tissue repair. Previously, the discovery of new drugs and
systems biology went hand in hand; although Systems biology as a term has only
originated in the last century. Various new chemicals were tested on the human
body, and studied through observation. Animal models replaced humans for initial
trials, but the interactions, response, dose and effect between animals and
humans could not be directly correlated. Therefore, there is a need to form
disease models outside of human subjects to check the effectiveness and response
of the newer natural or synthetic chemicals. These emulate human disease
conditions wherein the behavior of the chemicals would be similar in the disease
model and humans.