Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30042981
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30042981
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Tomography
2017 ; 3
(4
): 188-200
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to
Renal Magnetic Resonance Oximetry
#MMPMID30042981
Pohlmann A
; Cantow K
; Huelnhagen T
; Grosenick D
; Dos Santos Periquito J
; Boehmert L
; Gladytz T
; Waiczies S
; Flemming B
; Seeliger E
; Niendorf T
Tomography
2017[Dec]; 3
(4
): 188-200
PMID30042981
show ga
Diagnosis of early-stage acute kidney injury (AKI) will benefit from a timely
identification of local tissue hypoxia. Renal tissue hypoxia is an early feature
in AKI pathophysiology, and renal oxygenation is increasingly being assessed
through T(2)*-weighted magnetic resonance imaging (MRI). However, changes in
renal blood volume fraction (BVf) confound renal T(2)*. The aim of this study was
to assess the feasibility of intravascular contrast-enhanced MRI for monitoring
renal BVf during physiological interventions that are concomitant with variations
in BVf and to explore the possibility of correcting renal T(2)* for BVf
variations. A dose-dependent study of the contrast agent ferumoxytol was
performed in rats. BVf was monitored throughout short-term occlusion of the renal
vein, which is known to markedly change renal blood partial pressure of O(2) and
BVf. BVf calculated from MRI measurements was used to estimate oxygen saturation
of hemoglobin (SO(2)). BVf and SO(2) were benchmarked against cortical data
derived from near-infrared spectroscopy. As estimated from magnetic resonance
parametric maps of T(2) and T(2)*, BVf was shown to increase, whereas SO(2) was
shown to decline during venous occlusion (VO). This observation could be
quantitatively reproduced in test-retest scenarios. Changes in BVf and SO(2) were
in good agreement with data obtained from near-infrared spectroscopy. Our
findings provide motivation to advance multiparametric MRI for studying AKIs,
with the ultimate goal of translating MRI-based renal BVf mapping into clinical
practice en route noninvasive renal magnetic resonance oximetry as a method of
assessing AKI and progression to chronic damage.
free
free
free
