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10.3390/toxins10060218 http://scihub22266oqcxt.onion/10.3390/toxins10060218 C6024314!6024314!29844272     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxins+(Basel) 2018 ; 10 (6): ä Nephropedia Template TP {{tp|p=29844272|t=2018. The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function |pdf=|usr=}}{{29844272}} gab.com Text The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29844272 #FOAvip Chronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth muscle cell (VSMC) dysfunction has a key role in the remodeling process. Under uremic conditions, VSMCs can switch from a contractile phenotype to a synthetic phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis, and calcification. A growing body of data from experiments in vitro and animal models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate and advanced-glycation end products) may directly impact the VSMCs? physiological functions. Chronic, low-grade inflammation and oxidative stress?hallmarks of CKD?are also strong inducers of VSMC dysfunction. Here, we review current knowledge about the impact of uremic toxins on VSMC function in CKD, and the consequences for pathological vascular remodeling. Twit Text FOAVip The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29844272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844272 #FOAvip English Wikipedia <ref>{{Cite pmid|29844272}}</ref> The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function #MMPMID29844272 Hénaut L; Mary A; Chillon JM; Kamel S; Massy ZA Toxins (Basel) 2018[Jun]; 10 (6): ä PMID29844272show ga Chronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth muscle cell (VSMC) dysfunction has a key role in the remodeling process. Under uremic conditions, VSMCs can switch from a contractile phenotype to a synthetic phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis, and calcification. A growing body of data from experiments in vitro and animal models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate and advanced-glycation end products) may directly impact the VSMCs? physiological functions. Chronic, low-grade inflammation and oxidative stress?hallmarks of CKD?are also strong inducers of VSMC dysfunction. Here, we review current knowledge about the impact of uremic toxins on VSMC function in CKD, and the consequences for pathological vascular remodeling. äThe Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function (epmc).pdf DeepDyve Pubget Overpricing