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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Medicine+(Baltimore) 2018 ; 97 (24): ä Nephropedia Template TP
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Management of hepatic vein occlusive disease after liver transplantation: A case report with literature review #MMPMID29901618
Hou Y; Tam NL; Xue Z; Zhang X; Liao B; Yang J; Fu S; Ma Y; Wu L; He X
Medicine (Baltimore) 2018[Jun]; 97 (24): ä PMID29901618show ga
Rationale:: Hepatic vein occlusive disease (HVOD) is a rare complication after liver transplantation, which is characterized by nonthrombotic, fibrous obliteration of the small centrilobular hepatic veins by connective tissue and centrilobular necrosis in zone 3 of the acini. HVOD after solid organ transplantation has been reported; recently, most of these reports with limited cases have documented that acute cell rejection and immunosuppressive agents are the major causative factors. HVOD is relatively a rare complication of liver transplantation with the incidence of approximately 2%. Patient concerns:: A 59-year-old male patient with alcoholic liver cirrhosis underwent liver transplantation in our center. He suffered ascites, renal impairment 3 months after the surgery while liver enzymes were in normal range. Diagnoses:: Imagining and pathology showed no evidence of rejection or vessels complications. HVOD was diagnosed with pathology biopsy. Interventions:: Tacrolimus was withdrawn and the progression of HVOD was reversed. Outcomes:: Now, this patient has been followed up for 6 months after discharge with normal liver graft function. Lessons:: The use of tacrolimus in patients after liver transplantation may cause HVOD. Patients with jaundice, body weight gain, and refractory ascites should be strongly suspected of tacrolimus related HVOD.