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10.3389/fmicb.2018.01381 http://scihub22266oqcxt.onion/10.3389/fmicb.2018.01381 C6024001!6024001!29988394     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Microbiol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29988394|t=2018. Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection?A Prospective Pilot Study |pdf=|usr=}}{{29988394}} gab.com Text Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection A Prospective Pilot Study JO: Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=29988394 #FOAvip Background: Blood or tissue culture or histology prove invasive Candida infection, but long time to result, limited feasibility and sensitivity call for new approaches. In this pilot project, we describe the diagnostic potential of quantitating Candida-reactive, CD4/CD69/CD154 positive lymphocytes in blood of patients with invasive Candida infection.Methods: We used flow cytometry quantitating Candida-reactive, CD4/CD69/CD154 positive lymphocytes from peripheral blood of patients with invasive Candida infection, from patients at risk and healthy volunteers as controls.Results: Elevated levels of Candida-reactive lymphocytes were measured in 13 patients with proven invasive Candida infection and in one patient with probable hepatosplenic candidiasis. Results of three candidemia patients were uninterpretable due to autofluorescence of samples. Twelve of 13 patients had Candida identified to species level by conventional methods, and T cell reactivity correctly identified Candida species in 10 of 12 patients. Nine hematological high-risk patients and 14 healthy donors had no elevated Candida-reactive T cell counts.Conclusions: This Candida-reactive lymphocyte assay correctly identified the majority of patients with invasive Candida infection and the respective species. Our assay has the potential to support diagnosis of invasive Candida infection to species level and to facilitate tailored treatment even when biopsies are contraindicated or cultures remain negative. Twit Text FOAVip Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection A Prospective Pilot Study ????Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=29988394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29988394 #FOAvip English Wikipedia <ref>{{Cite pmid|29988394}}</ref> Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection?A Prospective Pilot Study #MMPMID29988394 Koehler FC; Cornely OA; Wisplinghoff H; Schauss AC; Salmanton-Garcia J; Ostermann H; Ziegler M; Bacher P; Scheffold A; Alex R; Richter A; Koehler P Front Microbiol 2018[]; 9 (ä): ä PMID29988394show ga Background: Blood or tissue culture or histology prove invasive Candida infection, but long time to result, limited feasibility and sensitivity call for new approaches. In this pilot project, we describe the diagnostic potential of quantitating Candida-reactive, CD4/CD69/CD154 positive lymphocytes in blood of patients with invasive Candida infection.Methods: We used flow cytometry quantitating Candida-reactive, CD4/CD69/CD154 positive lymphocytes from peripheral blood of patients with invasive Candida infection, from patients at risk and healthy volunteers as controls.Results: Elevated levels of Candida-reactive lymphocytes were measured in 13 patients with proven invasive Candida infection and in one patient with probable hepatosplenic candidiasis. Results of three candidemia patients were uninterpretable due to autofluorescence of samples. Twelve of 13 patients had Candida identified to species level by conventional methods, and T cell reactivity correctly identified Candida species in 10 of 12 patients. Nine hematological high-risk patients and 14 healthy donors had no elevated Candida-reactive T cell counts.Conclusions: This Candida-reactive lymphocyte assay correctly identified the majority of patients with invasive Candida infection and the respective species. Our assay has the potential to support diagnosis of invasive Candida infection to species level and to facilitate tailored treatment even when biopsies are contraindicated or cultures remain negative. äCandida-Reactive T Cells for the Diagnosis of Invasive Candida Infecti(epmc).pdf DeepDyve Pubget Overpricing