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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Cardiovasc+Dev+Dis 2018 ; 5 (2): ä Nephropedia Template TP
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Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments #MMPMID29751653
Pozdniakova S; Ladilov Y
J Cardiovasc Dev Dis 2018[Jun]; 5 (2): ä PMID29751653show ga
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3??5?-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One important player in cAMP signaling is soluble adenylyl cyclase (sAC). The intracellular localization of sAC allows for the formation of unique intracellular cAMP microdomains that control various physiological and pathological processes. This review is focused on the functional role of sAC-produced cAMP. In particular, we examine the role of sAC-cAMP in different cellular compartments, such as cytosol, nucleus and mitochondria.