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10.3390/antibiotics7020032 http://scihub22266oqcxt.onion/10.3390/antibiotics7020032 C6023003!6023003!29642475     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antibiotics+(Basel) 2018 ; 7 (2): ä Nephropedia Template TP {{tp|p=29642475|t=2018. Our Evolving Understanding of the Mechanism of Quinolones |pdf=|usr=}}{{29642475}} gab.com Text Our Evolving Understanding of the Mechanism of Quinolones JO: Antibiotics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29642475 #FOAvip The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled regions into the DNA double helix. Resolution of DNA supercoiling is essential to maintain DNA replication rates that are amenable to life. This resolution is handled by evolutionarily conserved enzymes known as topoisomerases. The activity of topoisomerases is essential, and therefore constitutes a prime candidate for targeting by antibiotics. In this review, we present hallmark investigations describing the mode of action of quinolones, one of the antibacterial classes targeting the function of topoisomerases in bacteria. By chronologically analyzing data gathered on the mode of action of this imperative antibiotic class, we highlight the necessity to look beyond primary drug-target interactions towards thoroughly understanding the mechanism of quinolones at the level of the cell. Twit Text FOAVip Our Evolving Understanding of the Mechanism of Quinolones ????Antibiotics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29642475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29642475 #FOAvip English Wikipedia <ref>{{Cite pmid|29642475}}</ref> Our Evolving Understanding of the Mechanism of Quinolones #MMPMID29642475 Gutierrez A; Stokes JM; Matic I Antibiotics (Basel) 2018[Jun]; 7 (2): ä PMID29642475show ga The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled regions into the DNA double helix. Resolution of DNA supercoiling is essential to maintain DNA replication rates that are amenable to life. This resolution is handled by evolutionarily conserved enzymes known as topoisomerases. The activity of topoisomerases is essential, and therefore constitutes a prime candidate for targeting by antibiotics. In this review, we present hallmark investigations describing the mode of action of quinolones, one of the antibacterial classes targeting the function of topoisomerases in bacteria. By chronologically analyzing data gathered on the mode of action of this imperative antibiotic class, we highlight the necessity to look beyond primary drug-target interactions towards thoroughly understanding the mechanism of quinolones at the level of the cell. äOur Evolving Understanding of the Mechanism of Quinolones (epmc).pdf DeepDyve Pubget Overpricing