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10.7717/peerj.5149 http://scihub22266oqcxt.onion/10.7717/peerj.5149 C6022720!6022720!29967758     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PeerJ 2018 ; 6 (ä): ä Nephropedia Template TP {{tp|p=29967758|t=2018. Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification |pdf=|usr=}}{{29967758}} gab.com Text Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification JO: PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=29967758 #FOAvip Effective approaches for assessing mitochondrial DNA (mtDNA) variation are important to multiple scientific disciplines. Mitochondrial haplogroups characterize branch points in the phylogeny of mtDNA. Several tools exist for mitochondrial haplogroup classification. However, most require full or partial mtDNA sequence which is often cost prohibitive for studies with large sample sizes. The purpose of this study was to develop Hi-MC, a high-throughput method for mitochondrial haplogroup classification that is cost effective and applicable to large sample sizes making mitochondrial analysis more accessible in genetic studies. Using rigorous selection criteria, we defined and validated a custom panel of mtDNA single nucleotide polymorphisms that allows for accurate classification of European, African, and Native American mitochondrial haplogroups at broad resolution with minimal genotyping and cost. We demonstrate that Hi-MC performs well in samples of European, African, and Native American ancestries, and that Hi-MC performs comparably to a commonly used classifier. Implementation as a software package in R enables users to download and run the program locally, grants greater flexibility in the number of samples that can be run, and allows for easy expansion in future revisions. Hi-MC is available in the CRAN repository and the source code is freely available at https://github.com/vserch/himc. Twit Text FOAVip Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification ????PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=29967758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29967758 #FOAvip English Wikipedia <ref>{{Cite pmid|29967758}}</ref> Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification #MMPMID29967758 Smieszek S; Mitchell SL; Farber-Eger EH; Veatch OJ; Wheeler NR; Goodloe RJ; Wells QS; Murdock DG; Crawford DC PeerJ 2018[]; 6 (ä): ä PMID29967758show ga Effective approaches for assessing mitochondrial DNA (mtDNA) variation are important to multiple scientific disciplines. Mitochondrial haplogroups characterize branch points in the phylogeny of mtDNA. Several tools exist for mitochondrial haplogroup classification. However, most require full or partial mtDNA sequence which is often cost prohibitive for studies with large sample sizes. The purpose of this study was to develop Hi-MC, a high-throughput method for mitochondrial haplogroup classification that is cost effective and applicable to large sample sizes making mitochondrial analysis more accessible in genetic studies. Using rigorous selection criteria, we defined and validated a custom panel of mtDNA single nucleotide polymorphisms that allows for accurate classification of European, African, and Native American mitochondrial haplogroups at broad resolution with minimal genotyping and cost. We demonstrate that Hi-MC performs well in samples of European, African, and Native American ancestries, and that Hi-MC performs comparably to a commonly used classifier. Implementation as a software package in R enables users to download and run the program locally, grants greater flexibility in the number of samples that can be run, and allows for easy expansion in future revisions. Hi-MC is available in the CRAN repository and the source code is freely available at https://github.com/vserch/himc. äHi-MC: a novel method for high-throughput mitochondrial haplogroup cla(epmc).pdf DeepDyve Pubget Overpricing