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10.1093/bioinformatics/bty263

http://scihub22266oqcxt.onion/10.1093/bioinformatics/bty263
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C6022650!6022650!29950017
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suck abstract from ncbi


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pmid29950017      Bioinformatics 2018 ; 34 (13): i386-94
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  • A gene?phenotype relationship extraction pipeline from the biomedical literature using a representation learning approach #MMPMID29950017
  • Xing W; Qi J; Yuan X; Li L; Zhang X; Fu Y; Xiong S; Hu L; Peng J
  • Bioinformatics 2018[Jul]; 34 (13): i386-94 PMID29950017show ga
  • Motivation: The fundamental challenge of modern genetic analysis is to establish gene-phenotype correlations that are often found in the large-scale publications. Because lexical features of gene are relatively regular in text, the main challenge of these relation extraction is phenotype recognition. Due to phenotypic descriptions are often study- or author-specific, few lexicon can be used to effectively identify the entire phenotypic expressions in text, especially for plants. Results: We have proposed a pipeline for extracting phenotype, gene and their relations from biomedical literature. Combined with abbreviation revision and sentence template extraction, we improved the unsupervised word-embedding-to-sentence-embedding cascaded approach as representation learning to recognize the various broad phenotypic information in literature. In addition, the dictionary- and rule-based method was applied for gene recognition. Finally, we integrated one of famous information extraction system OLLIE to identify gene-phenotype relations. To demonstrate the applicability of the pipeline, we established two types of comparison experiment using model organism Arabidopsis thaliana. In the comparison of state-of-the-art baselines, our approach obtained the best performance (F1-Measure of 66.83%). We also applied the pipeline to 481 full-articles from TAIR gene-phenotype manual relationship dataset to prove the validity. The results showed that our proposed pipeline can cover 70.94% of the original dataset and add 373 new relations to expand it. Availability and implementation: The source code is available at http://www.wutbiolab.cn: 82/Gene-Phenotype-Relation-Extraction-Pipeline.zip. Supplementary information: Supplementary data are available at Bioinformatics online.
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