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10.2147/DDDT.S162950 http://scihub22266oqcxt.onion/10.2147/DDDT.S162950 C6021006!6021006 !29970958     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29970958 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Des+Devel+Ther 2018 ; 12 (ä): 1837-1853 Nephropedia Template TP {{tp|p=29970958 |t=2018. Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-?B and TGF-?1/Smad3 pathways |pdf=|usr=}}{{29970958 }} gab.com Text Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF- B and TGF- 1/Smad3 pathways JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=29970958 #FOAvip PURPOSE: Liver fibrosis is commonly seen and a necessary stage in chronic liver disease. The aim of this study was to explore the effect of salidroside on liver fibrosis in mice and its potential mechanisms. MATERIALS AND METHODS: Two mouse liver fibrosis models were established by intraperitoneal injection of carbon tetrachloride (CCl(4)) for 8 weeks and bile duct ligation for 14 days. Salidroside was injected intraperitoneally at doses of 10 and 20 mg/kg once a day. Gene and protein expression levels were determined by quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, Western blot, immunohistochemistry, and immunofluorescence. RESULTS: Salidroside inhibited the production of extracellular matrix (ECM) and regulated the balance between MMP2 and TIMP1 and, therefore, alleviated liver fibrosis in the two fibrosis models. Salidroside reduced the production of transforming growth factor (TGF)-?1 in Kupffer cells and hepatic stellate cells (HSCs) via the nuclear factor-?B signaling pathway and, therefore, inhibited the activation of HSCs and autophagy by downregulation of the TGF-?1/Smad3 signaling pathway. CONCLUSION: Salidroside can effectively attenuate liver fibrosis by inhibiting the activation of HSCs in mice. Twit Text FOAVip Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF- B and TGF- 1/Smad3 pathways ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=29970958 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29970958 #FOAvip English Wikipedia <ref>{{Cite pmid|29970958 }}</ref> Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-?B and TGF-?1/Smad3 pathways #MMPMID29970958 Feng J ; Chen K ; Xia Y ; Wu L ; Li J ; Li S ; Wang W ; Lu X ; Liu T ; Guo C Drug Des Devel Ther 2018[]; 12 (ä): 1837-1853 PMID29970958 show ga PURPOSE: Liver fibrosis is commonly seen and a necessary stage in chronic liver disease. The aim of this study was to explore the effect of salidroside on liver fibrosis in mice and its potential mechanisms. MATERIALS AND METHODS: Two mouse liver fibrosis models were established by intraperitoneal injection of carbon tetrachloride (CCl(4)) for 8 weeks and bile duct ligation for 14 days. Salidroside was injected intraperitoneally at doses of 10 and 20 mg/kg once a day. Gene and protein expression levels were determined by quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, Western blot, immunohistochemistry, and immunofluorescence. RESULTS: Salidroside inhibited the production of extracellular matrix (ECM) and regulated the balance between MMP2 and TIMP1 and, therefore, alleviated liver fibrosis in the two fibrosis models. Salidroside reduced the production of transforming growth factor (TGF)-?1 in Kupffer cells and hepatic stellate cells (HSCs) via the nuclear factor-?B signaling pathway and, therefore, inhibited the activation of HSCs and autophagy by downregulation of the TGF-?1/Smad3 signaling pathway. CONCLUSION: Salidroside can effectively attenuate liver fibrosis by inhibiting the activation of HSCs in mice. |Animals [MESH] |Autophagy/*drug effects [MESH] |Glucosides/*pharmacology [MESH] |Hepatic Stellate Cells/*drug effects [MESH] |Liver Cirrhosis/drug therapy [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/*physiology [MESH] |Phenols/*pharmacology [MESH] |Signal Transduction/*drug effects [MESH] |Smad3 Protein/*physiology [MESH]Salidroside ameliorates autophagy and activation of hepatic stellate c(epmc).pdf DeepDyve Pubget Overpricing