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10.1186/s12931-018-0832-x

http://scihub22266oqcxt.onion/10.1186/s12931-018-0832-x
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C6019726!6019726!29940981
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suck abstract from ncbi


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pmid29940981      Respir+Res 2018 ; 19 (ä): ä
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  • Interleukin-32: its role in asthma and potential as a therapeutic agent #MMPMID29940981
  • Xin T; Chen M; Duan L; Xu Y; Gao P
  • Respir Res 2018[]; 19 (ä): ä PMID29940981show ga
  • Interleukin (IL)-32, also named natural killer cell transcript 4 (NK4), has increasingly been described as an immunoregulator that controls cell differentiation and cell death and is involved in the stimulation of anti?/pro-inflammatory cytokines. Abnormal presence of IL-32 has been repeatedly noticed during the pathogenesis of allergic, infectious, cancerous, and inflammatory diseases. Of particular note was the observation of the anti-inflammatory property of IL-32 in a murine ovalbumin model of allergic asthma. Compared to wild-type mice, IL-32? transgenic mice show decreased levels of inflammatory cells, recruited eosinophils, and lymphocytes in bronchoalveolar lavage fluid in a mouse model of acute asthma. To date, the molecular mechanism underlying the role of IL-32 in asthma remains to be elucidated. This review aims to summarize recent advances in the pathophysiology of asthma and describe the links to IL-32. The possibilities of using IL-32 as an airway inflammation biomarker and an asthma therapeutic agent are also evaluated.
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