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10.3389/fimmu.2018.01407 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.01407 C6019438!6019438!29973939     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29973939|t=2018. Transforming Growth Factor-?1/Smad7 in Intestinal Immunity, Inflammation, and Cancer |pdf=|usr=}}{{29973939}} gab.com Text Transforming Growth Factor- 1/Smad7 in Intestinal Immunity, Inflammation, and Cancer JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29973939 #FOAvip In physiological conditions, the activity of the intestinal immune system is tightly regulated to prevent tissue-damaging reactions directed against components of the luminal flora. Various factors contribute to maintain immune homeostasis and diminished production and/or function of such molecules trigger and/or propagate detrimental signals, which can eventually lead to chronic colitis and colon cancer. One such a molecule is transforming growth factor-?1 (TGF-?1), a cytokine produced by many inflammatory and non-inflammatory cells and targeting virtually all the intestinal mucosal cell types, with the down-stream effect of activating intracellular Smad2/3 proteins and suppressing immune reactions. In patients with inflammatory bowel diseases (IBD), there is defective TGF-?1/Smad signaling due to high Smad7, an inhibitor of TGF-?1 activity. Indeed, knockdown of Smad7 with a specific antisense oligonucleotide restores endogenous TGF-?1 activity, thereby inhibiting inflammatory pathways in patients with IBD and colitic mice. Consistently, mice over-expressing Smad7 in T cells develop severe intestinal inflammation in various experimental models. Smad7 expression is also upregulated in colon cancer cells, in which such a protein controls positively intracellular pathways that sustain neoplastic cell growth and survival. We here review the role of TGF-?1 and Smad7 in intestinal immunity, inflammation, and cancer. Twit Text FOAVip Transforming Growth Factor- 1/Smad7 in Intestinal Immunity, Inflammation, and Cancer ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29973939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29973939 #FOAvip English Wikipedia <ref>{{Cite pmid|29973939}}</ref> Transforming Growth Factor-?1/Smad7 in Intestinal Immunity, Inflammation, and Cancer #MMPMID29973939 Troncone E; Marafini I; Stolfi C; Monteleone G Front Immunol 2018[]; 9 (ä): ä PMID29973939show ga In physiological conditions, the activity of the intestinal immune system is tightly regulated to prevent tissue-damaging reactions directed against components of the luminal flora. Various factors contribute to maintain immune homeostasis and diminished production and/or function of such molecules trigger and/or propagate detrimental signals, which can eventually lead to chronic colitis and colon cancer. One such a molecule is transforming growth factor-?1 (TGF-?1), a cytokine produced by many inflammatory and non-inflammatory cells and targeting virtually all the intestinal mucosal cell types, with the down-stream effect of activating intracellular Smad2/3 proteins and suppressing immune reactions. In patients with inflammatory bowel diseases (IBD), there is defective TGF-?1/Smad signaling due to high Smad7, an inhibitor of TGF-?1 activity. Indeed, knockdown of Smad7 with a specific antisense oligonucleotide restores endogenous TGF-?1 activity, thereby inhibiting inflammatory pathways in patients with IBD and colitic mice. Consistently, mice over-expressing Smad7 in T cells develop severe intestinal inflammation in various experimental models. Smad7 expression is also upregulated in colon cancer cells, in which such a protein controls positively intracellular pathways that sustain neoplastic cell growth and survival. We here review the role of TGF-?1 and Smad7 in intestinal immunity, inflammation, and cancer. äTransforming Growth Factor-?1/Smad7 in Intestinal Immunity, Inflammati(epmc).pdf DeepDyve Pubget Overpricing