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2018 ; 13
(6
): e0199301
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Different composition of intraocular immune mediators in
Posner-Schlossman-Syndrome and Fuchs Uveitis
#MMPMID29944680
Pohlmann D
; Schlickeiser S
; Metzner S
; Lenglinger M
; Winterhalter S
; Pleyer U
PLoS One
2018[]; 13
(6
): e0199301
PMID29944680
show ga
Posner-Schlossman-Syndrome (PSS) is clinically characterized by acute, recurrent,
mild, unilateral uveitis anterior accompanied by elevated intraocular pressure
(IOP). Fuchs´ Uveitis (FU) is a chronic, low-grade-inflammatory disorder,
involving anterior uvea and vitreous. The clinical findings show remarkable
similarities as well as differences. In our study, we determine the composition
of immune mediators in aqueous humor of patients with PSS and FU and evaluate if
immune mediators play a crucial role in specific viral intraocular inflammation
and IOP rises. Aqueous humor samples from 81 uveitis patients (= eyes) presenting
with either PSS or FU were collected at one time point. Local intraocular
antibody synthesis to rubella virus was confirmed in 65 patients, whereas 16 were
tested positively for human cytomegalovirus. Thirteen patients with PSS and 10
patients with FU were treated with glaucoma medications. Additionally, 11
cataract patients acted as control group. Immune mediator concentrations were
measured by Bio-Plex Pro assay. We observed in both PSS (IFN-?: 174.9 pg/mL;
TNF-?: 25.1 pg/mL) and FU (IFN-?: 25.4 pg/mL; TNF-?: 27.2 pg/mL) groups a
significantly increased level of T-helper 1 immune mediators compared to controls
(IFN-?, TNF-?: 0 pg/mL) [median]. Notably, PSS patients (IL-1RA: 73.4 pg/mL;
IL-8: 199.4 pg/mL; IL-10: 33.4 pg/mL; IP-10: 126350 pg/mL) showed a stronger and
more active ocular inflammatory response, than FU patients (IL-1RA: 4.3 pg/mL;
IL-8: 72.4 pg/mL; IL-10: 1.6 pg/mL; IP-10: 57400 pg/mL). Furthermore, a negative
correlation between mediators and IOP was seen in the PSS group, potentially
caused by acetazolamide-treatment. Our findings show that immune mediators play a
crucial role in specific viral intraocular inflammation and influence IOP levels.
Remarkable similarities but also significant differences of immune mediator
concentrations are apparent in PSS compared to FU. High concentrations of IL-1RA,
IL-8, IL-10, and IP-10 correlate with active inflammation in PSS, while FU may
trigger chronic inflammation. Our data also substantiated a very similar
composition of cytokines in those patients from the PSS group suffering from
ocular hypertension and thus offers a potential explanation model for a negative
correlation between mediators and IOP.
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