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10.7554/eLife.36806 http://scihub22266oqcxt.onion/10.7554/eLife.36806 C6019063!6019063!29943728     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2018 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29943728|t=2018. NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity |pdf=|usr=}}{{29943728}} gab.com Text NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=29943728 #FOAvip Antibodies acquired naturally through repeated exposure to Plasmodium falciparum are essential in the control of blood-stage malaria. Antibody-dependent functions may include neutralization of parasite?host interactions, complement activation, and activation of Fc receptor functions. A role of antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells in protection from malaria has not been established. Here we show that IgG isolated from adults living in a malaria-endemic region activated ADCC by primary human NK cells, which lysed infected red blood cells (RBCs) and inhibited parasite growth in an in vitro assay for ADCC-dependent growth inhibition. RBC lysis by NK cells was highly selective for infected RBCs in a mixed culture with uninfected RBCs. Human antibodies to P. falciparum antigens PfEMP1 and RIFIN were sufficient to promote NK-dependent growth inhibition. As these results implicate acquired immunity through NK-mediated ADCC, antibody-based vaccines that target bloodstream parasites should consider this new mechanism of action. Twit Text FOAVip NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=29943728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29943728 #FOAvip English Wikipedia <ref>{{Cite pmid|29943728}}</ref> NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity #MMPMID29943728 Arora G; Hart GT; Manzella-Lapeira J; Doritchamou JY; Narum DL; Thomas LM; Brzostowski J; Rajagopalan S; Doumbo OK; Traore B; Miller LH; Pierce SK; Duffy PE; Crompton PD; Desai SA; Long EO eLife 2018[]; 7 (ä): ä PMID29943728show ga Antibodies acquired naturally through repeated exposure to Plasmodium falciparum are essential in the control of blood-stage malaria. Antibody-dependent functions may include neutralization of parasite?host interactions, complement activation, and activation of Fc receptor functions. A role of antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells in protection from malaria has not been established. Here we show that IgG isolated from adults living in a malaria-endemic region activated ADCC by primary human NK cells, which lysed infected red blood cells (RBCs) and inhibited parasite growth in an in vitro assay for ADCC-dependent growth inhibition. RBC lysis by NK cells was highly selective for infected RBCs in a mixed culture with uninfected RBCs. Human antibodies to P. falciparum antigens PfEMP1 and RIFIN were sufficient to promote NK-dependent growth inhibition. As these results implicate acquired immunity through NK-mediated ADCC, antibody-based vaccines that target bloodstream parasites should consider this new mechanism of action. äNK cells inhibit Plasmodium falciparum growth in red blood cells via a(epmc).pdf DeepDyve Pubget Overpricing