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2018 ; 9
(ä): 701
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Dental Findings in Patients With Non-surgical Hypoparathyroidism and
Pseudohypoparathyroidism: A Systematic Review
#MMPMID29971010
Hejlesen J
; Underbjerg L
; Gjørup H
; Bloch-Zupan A
; Sikjaer T
; Rejnmark L
; Haubek D
Front Physiol
2018[]; 9
(ä): 701
PMID29971010
show ga
Background: Dental aberrations have been mentioned in relation to non-surgical
hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a
systematic review of dental characteristics have not been performed. The present
systematic review describes the dental findings in patients with Ns-HypoPT and
PHP. Methods: Studies on Ns-HypoPT and PHP reporting dental features were
eligible. A systematic literature search was conducted using four bibliographic
databases (Web of Science, Scopus, Pubmed, and Embase) and was limited to studies
written in English. Reviews, meta-analyses and letters were excluded. Both the
research and reporting of results were based on PRISMA (preferred Reporting Items
for Systematic Reviews and Meta-Analysis) guidelines. Results: Of 88 studies
included, nine were cross-sectional, one was a prospective cohort study, 26 were
case series, and 52 were case reports. The most frequently reported findings in
patients with Ns-HypoPT were enamel opacities, enamel hypoplasia, hypodontia, and
eruption disturbances. In patients with PHP, enamel hypoplasia, eruption
disturbance, and deviation of the root morphology were the most frequently
reported findings. Conclusion: An association between enamel hypoplasia and
Ns-HypoPT and PHP is likely. The results should, however, be interpreted
cautiously due to the limited number of high-quality studies. The present review
confirms the need of further well-designed studies, such as large-scale studies,
e.g., multicenter studies, to conclude on the reported associations between
Ns-HypoPT/PHP and enamel hypoplasia.