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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Pharmacol
2018 ; 9
(ä): 238
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Efficacy and Safety of Cyclosporine in Acute Myocardial Infarction: A Systematic
Review and Meta-Analysis
#MMPMID29970999
Rahman FA
; Abdullah SS
; Manan WZWA
; Tan LT
; Neoh CF
; Ming LC
; Chan KG
; Lee LH
; Goh BH
; Salmasi S
; Wu DB
; Khan TM
Front Pharmacol
2018[]; 9
(ä): 238
PMID29970999
show ga
There are various studies that have addressed the use of Cyclosporine among
patients with acute myocardial infarction (AMI). However, to date there is hardly
any concise and systematically structured evidence that debate on the efficacy
and safety of Cyclosporine in AMI patients. The aim of this review is to
systematically summarize the overall evidence from published trials, and to
conduct a meta-analysis in order to determine the efficacy and safety of
Cyclosporine vs. placebo or control among patients with AMI. All randomized
control trial (RCT) published in English language from January 2000 to August
2017 were included for the systematic review and meta-analysis. A total of six
RCTs met the inclusion and were hence included in the systematic review and
meta-analysis. Based on the performed meta-analysis, no significant difference
was found between Cyclosporine and placebo in terms of left ventricular ejection
fraction (LVEF) improvement (mean difference 1.88; 95% CI -0.99 to 4.74; P =
0.2), mortality rate (OR 1.01; 95% Cl 0.60 to 1.67, P = 0.98) and recurrent MI
occurrence (OR 0.65; 95% Cl 0.29 to 1.45, P = 0.29), with no evidence of
heterogeneity, when given to patients with AMI. Cyclosporine also did not
significantly lessen the rate of rehospitalisation in AMI patients when compared
to placebo (OR 0.91; 95% Cl 0.58 to 1.42, P = 0.68), with moderate heterogeneity
(I(2) = 46%). There was also no significant improvement in heart failure events
between Cyclosporine and placebo in AMI patients (OR 0.63; 95% Cl 0.31 to 1.29, P
= 0.21; I(2) = 80%). No serious adverse events were reported in Cyclosporine
group across all studies suggesting that Cyclosporine is well tolerated when
given to patients with AMI. The use of Cyclosporine in this group of patients,
however, did not result in better clinical outcomes vs. placebo at improving
LVEF, mortality rate, recurrent MI, rehospitalisation and heart failure event.
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