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10.1186/s10020-018-0006-9 http://scihub22266oqcxt.onion/10.1186/s10020-018-0006-9 C6016887/?report=reader!6016887!30134814     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med 2018 ; 24 (ä): ä Nephropedia Template TP {{tp|p=30134814|t=2018. Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity |pdf=|usr=}}{{30134814}} gab.com Text Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=30134814 #FOAvip Background: The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1? and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote survival during endotoxemia and experimental sepsis. However, the underlying protective mechanism remains elusive. Result: EP dose-dependently inhibited the ATP-, nigericin-, alum-, and silica-induced caspase-1 activation and HMGB1 release in mouse macrophages. EP failed to inhibit DNA transfection- or Salmonella Typhimurium-induced caspase-1 activation and HMGB1 release. Mechanistically, EP significantly attenuated mitochondrial damage and cytoplasmic translocation of mitochondrial DNA, a known NLRP3 ligand, without influencing the potassium efflux, the lysosomal rupture or the production of mitochondrial reactive oxygen species (mtROS). Conclusion: Ethyl pyruvate acts as a novel NLRP3 inflammasome inhibitor that preserves the integrity of mitochondria during inflammation. Twit Text FOAVip Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=30134814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30134814 #FOAvip English Wikipedia <ref>{{Cite pmid|30134814}}</ref> Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity #MMPMID30134814 Li S; Liang F; Kwan K; Tang Y; Wang X; Tang Y; Li J; Yang H; Chavan SS; Wang H; Andersson U; Lu B; Tracey KJ Mol Med 2018[]; 24 (ä): ä PMID30134814show ga Background: The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1? and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote survival during endotoxemia and experimental sepsis. However, the underlying protective mechanism remains elusive. Result: EP dose-dependently inhibited the ATP-, nigericin-, alum-, and silica-induced caspase-1 activation and HMGB1 release in mouse macrophages. EP failed to inhibit DNA transfection- or Salmonella Typhimurium-induced caspase-1 activation and HMGB1 release. Mechanistically, EP significantly attenuated mitochondrial damage and cytoplasmic translocation of mitochondrial DNA, a known NLRP3 ligand, without influencing the potassium efflux, the lysosomal rupture or the production of mitochondrial reactive oxygen species (mtROS). Conclusion: Ethyl pyruvate acts as a novel NLRP3 inflammasome inhibitor that preserves the integrity of mitochondria during inflammation. äIdentification of ethyl pyruvate as a NLRP3 inflammasome inhibitor tha(epmc).pdf DeepDyve Pubget Overpricing