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10.1186/s10020-018-0005-x http://scihub22266oqcxt.onion/10.1186/s10020-018-0005-x C6016884/?report=reader!6016884!30134787     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30134787&cmd=llinks): Failed to open stream: HTTP request failed! 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Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction |pdf=|usr=}}{{30134787}} gab.com Text Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=30134787 #FOAvip Background: Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve. However, despite the high prevalence of HF with preserved ejection fraction (HFpEF) in our society, it is not clear what changes in cardiac energy metabolism occur in HFpEF, and whether alterations in energy metabolism contribute to the development of contractile dysfunction. Methods: We directly assessed overall energy metabolism during the development of HFpEF in Dahl salt-sensitive rats fed a high salt diet (HSD) for 3, 6 and 9 weeks. Results: Over the course of 9 weeks, the HSD caused a progressive decrease in diastolic function (assessed by echocardiography assessment of E?/A?). This was accompanied by a progressive increase in cardiac glycolysis rates (assessed in isolated working hearts obtained at 3, 6, and 9 weeks of HSD). In contrast, the subsequent oxidation of pyruvate from glycolysis (glucose oxidation) was not altered, resulting in an uncoupling of glucose metabolism and a significant increase in proton production. Increased glucose transporter (GLUT)1 expression accompanied this elevation in glycolysis. Decreases in cardiac fatty acid oxidation and overall adenosine triphosphate (ATP) production rates were not observed in early HF, but both significantly decreased as HF progressed to HF with reduced EF (i.e. 9 weeks of HSD). Conclusions: Overall, we show that increased glycolysis is the earliest energy metabolic change that occurs during HFpEF development. The resultant increased proton production from uncoupling of glycolysis and glucose oxidation may contribute to the development of HFpEF. Electronic supplementary material: The online version of this article (10.1186/s10020-018-0005-x) contains supplementary material, which is available to authorized users. Twit Text FOAVip Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=30134787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30134787 #FOAvip English Wikipedia <ref>{{Cite pmid|30134787}}</ref> Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction #MMPMID30134787 Fillmore N; Levasseur JL; Fukushima A; Wagg CS; Wang W; Dyck JRB; Lopaschuk GD Mol Med 2018[]; 24 (ä): ä PMID30134787show ga Background: Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve. However, despite the high prevalence of HF with preserved ejection fraction (HFpEF) in our society, it is not clear what changes in cardiac energy metabolism occur in HFpEF, and whether alterations in energy metabolism contribute to the development of contractile dysfunction. Methods: We directly assessed overall energy metabolism during the development of HFpEF in Dahl salt-sensitive rats fed a high salt diet (HSD) for 3, 6 and 9 weeks. Results: Over the course of 9 weeks, the HSD caused a progressive decrease in diastolic function (assessed by echocardiography assessment of E?/A?). This was accompanied by a progressive increase in cardiac glycolysis rates (assessed in isolated working hearts obtained at 3, 6, and 9 weeks of HSD). In contrast, the subsequent oxidation of pyruvate from glycolysis (glucose oxidation) was not altered, resulting in an uncoupling of glucose metabolism and a significant increase in proton production. Increased glucose transporter (GLUT)1 expression accompanied this elevation in glycolysis. Decreases in cardiac fatty acid oxidation and overall adenosine triphosphate (ATP) production rates were not observed in early HF, but both significantly decreased as HF progressed to HF with reduced EF (i.e. 9 weeks of HSD). Conclusions: Overall, we show that increased glycolysis is the earliest energy metabolic change that occurs during HFpEF development. The resultant increased proton production from uncoupling of glycolysis and glucose oxidation may contribute to the development of HFpEF. Electronic supplementary material: The online version of this article (10.1186/s10020-018-0005-x) contains supplementary material, which is available to authorized users. äUncoupling of glycolysis from glucose oxidation accompanies the develo(epmc).pdf DeepDyve Pubget Overpricing