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10.1007/s00441-017-2759-9 http://scihub22266oqcxt.onion/10.1007/s00441-017-2759-9 C6015615!6015615!29308544     free     free     free       Cell+Tissue+Res 2018 ; 373 (1): 39-50 Nephropedia Template TP {{tp|p=29308544|t=2018. The LRRK2 signalling system |pdf=|usr=}}{{29308544}} gab.com Text The LRRK2 signalling system JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=29308544 #FOAvip The LRRK2 gene is a major contributor to genetic risk for Parkinson?s disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson?s research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review.Electronic supplementary material: The online version of this article (10.1007/s00441-017-2759-9) contains supplementary material, which is available to authorized users. Twit Text FOAVip The LRRK2 signalling system ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=29308544 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29308544 #FOAvip English Wikipedia <ref>{{Cite pmid|29308544}}</ref> The LRRK2 signalling system #MMPMID29308544 Price A; Manzoni C; Cookson MR; Lewis PA Cell Tissue Res 2018[]; 373 (1): 39-50 PMID29308544show ga The LRRK2 gene is a major contributor to genetic risk for Parkinson?s disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson?s research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review.Electronic supplementary material: The online version of this article (10.1007/s00441-017-2759-9) contains supplementary material, which is available to authorized users. äThe LRRK2 signalling system (epmc).pdf DeepDyve Pubget Overpricing