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10.1007/s00441-017-2759-9 http://scihub22266oqcxt.onion/10.1007/s00441-017-2759-9 C6015615!6015615 !29308544     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29308544 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Tissue+Res 2018 ; 373 (1 ): 39-50 Nephropedia Template TP {{tp|p=29308544 |t=2018. The LRRK2 signalling system |pdf=|usr=}}{{29308544 }} gab.com Text The LRRK2 signalling system JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=29308544 #FOAvip The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review. Twit Text FOAVip The LRRK2 signalling system ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=29308544 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29308544 #FOAvip English Wikipedia <ref>{{Cite pmid|29308544 }}</ref> The LRRK2 signalling system #MMPMID29308544 Price A ; Manzoni C ; Cookson MR ; Lewis PA Cell Tissue Res 2018[Jul]; 373 (1 ): 39-50 PMID29308544 show ga The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review. |*Signal Transduction [MESH] |Animals [MESH] |Humans [MESH] |Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics/*metabolism [MESH] |Models, Biological [MESH] |Mutation/genetics [MESH]The LRRK2 signalling system (epmc).pdf DeepDyve Pubget Overpricing