Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s13072-018-0204-2 http://scihub22266oqcxt.onion/10.1186/s13072-018-0204-2 C6015472!6015472!29933745     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics+Chromatin 2018 ; 11 (ä): ä Nephropedia Template TP {{tp|p=29933745|t=2018. Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx |pdf=|usr=}}{{29933745}} gab.com Text Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx JO: Epigenetics Chromatin http://www.kidney.de/pget.php?&tw=1&pmid=29933745 #FOAvip Background: In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional nuclear localization of cccDNA and HBx remains unexplored. Results: To identify virus?host genome interactions and the underlying nuclear landscape for the first time, we combined circular chromosome conformation capture (4C) with RNA-seq and ChIP-seq. Moreover, we studied HBx-binding to HBV episomes. In HBV-positive HepaRG hepatocytes, we observed preferential association of HBV episomes and HBx with actively transcribed nuclear domains on the host genome correlating in size with constrained topological units of chromatin. Interestingly, HBx alone occupied transcribed chromatin domains. Silencing of native HBx caused reduced episomal HBV stability. Conclusions: As part of the HBV episome, HBx might stabilize HBV episomal nuclear localization. Our observations may contribute to the understanding of long-term episomal stability and the facilitation of viral persistence. The exact mechanism by which HBx contributes to HBV nuclear persistence warrants further investigations. Electronic supplementary material: The online version of this article (10.1186/s13072-018-0204-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx ????Epigenetics Chromatin http://www.kidney.de/pget.php?&tw=1&pmid=29933745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29933745 #FOAvip English Wikipedia <ref>{{Cite pmid|29933745}}</ref> Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx #MMPMID29933745 Hensel KO; Cantner F; Bangert F; Wirth S; Postberg J Epigenetics Chromatin 2018[]; 11 (ä): ä PMID29933745show ga Background: In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional nuclear localization of cccDNA and HBx remains unexplored. Results: To identify virus?host genome interactions and the underlying nuclear landscape for the first time, we combined circular chromosome conformation capture (4C) with RNA-seq and ChIP-seq. Moreover, we studied HBx-binding to HBV episomes. In HBV-positive HepaRG hepatocytes, we observed preferential association of HBV episomes and HBx with actively transcribed nuclear domains on the host genome correlating in size with constrained topological units of chromatin. Interestingly, HBx alone occupied transcribed chromatin domains. Silencing of native HBx caused reduced episomal HBV stability. Conclusions: As part of the HBV episome, HBx might stabilize HBV episomal nuclear localization. Our observations may contribute to the understanding of long-term episomal stability and the facilitation of viral persistence. The exact mechanism by which HBx contributes to HBV nuclear persistence warrants further investigations. Electronic supplementary material: The online version of this article (10.1186/s13072-018-0204-2) contains supplementary material, which is available to authorized users. äEpisomal HBV persistence within transcribed host nuclear chromatin com(epmc).pdf DeepDyve Pubget Overpricing