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10.1161/JAHA.117.008281 http://scihub22266oqcxt.onion/10.1161/JAHA.117.008281 C6015301!6015301!29739797     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Heart+Assoc 2018 ; 7 (10): ä Nephropedia Template TP {{tp|p=29739797|t=2018. Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II |pdf=|usr=}}{{29739797}} gab.com Text Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=29739797 #FOAvip Background: DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not stable. We demonstrate that stimulatory signals can change the DNA methylation status around transcription factor binding sites and a transcription start site and activate expression of the aldosterone synthase gene (CYP11B2). Methods and Results: DNA methylation of CYP11B2 was analyzed in aldosterone?producing adenomas, nonfunctioning adrenal adenomas, and adrenal glands and compared with the gene expression levels. CpG dinucleotides in the CYP11B2 promoter were found to be hypormethylated in tissues with high expression, but not in those with low expression, of CYP11B2. Methylation of the CYP11B2 promoter fused to a reporter gene decreased transcriptional activity. Methylation of recognition sequences of transcription factors, including CREB1, NGFIB (NR4A1), and NURR1 (NR4A2) diminished their DNA?binding activity. A methylated?CpG?binding protein MECP2 interacted directly with the methylated CYP11B2 promoter. In rats, low salt intake led to upregulation of CYP11B2 expression and DNA hypomethylation in the adrenal gland. Treatment with angiotensin II type 1 receptor antagonist decreased CYP11B2 expression and led to DNA hypermethylation. Conclusions: DNA demethylation may switch the phenotype of CYP11B2 expression from an inactive to an active state and regulate aldosterone biosynthesis. Twit Text FOAVip Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=29739797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29739797 #FOAvip English Wikipedia <ref>{{Cite pmid|29739797}}</ref> Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II #MMPMID29739797 Takeda Y; Demura M; Wang F; Karashima S; Yoneda T; Kometani M; Hashimoto A; Aono D; Horike S; Meguro?Horike M; Yamagishi M; Takeda Y J Am Heart Assoc 2018[May]; 7 (10): ä PMID29739797show ga Background: DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not stable. We demonstrate that stimulatory signals can change the DNA methylation status around transcription factor binding sites and a transcription start site and activate expression of the aldosterone synthase gene (CYP11B2). Methods and Results: DNA methylation of CYP11B2 was analyzed in aldosterone?producing adenomas, nonfunctioning adrenal adenomas, and adrenal glands and compared with the gene expression levels. CpG dinucleotides in the CYP11B2 promoter were found to be hypormethylated in tissues with high expression, but not in those with low expression, of CYP11B2. Methylation of the CYP11B2 promoter fused to a reporter gene decreased transcriptional activity. Methylation of recognition sequences of transcription factors, including CREB1, NGFIB (NR4A1), and NURR1 (NR4A2) diminished their DNA?binding activity. A methylated?CpG?binding protein MECP2 interacted directly with the methylated CYP11B2 promoter. In rats, low salt intake led to upregulation of CYP11B2 expression and DNA hypomethylation in the adrenal gland. Treatment with angiotensin II type 1 receptor antagonist decreased CYP11B2 expression and led to DNA hypermethylation. Conclusions: DNA demethylation may switch the phenotype of CYP11B2 expression from an inactive to an active state and regulate aldosterone biosynthesis. äEpigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angio(epmc).pdf DeepDyve Pubget Overpricing